Special Senses System

Eye, Vitreous - Fibrosis

    Narrative
    Eye, Vitreous - Fibrosis in a male F344/N rat from a chronic study. There is loose fibrous connective tissue (asterisk) in the vitreous space between a cataractous lens (L) and a detached, degenerate retina (R).
    Eye, Vitreous - Fibrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). There is loose fibrous connective tissue (asterisk) with space scattered pigmented macrophages (arrow) in the vitreous; L = cataractous lens.
    Eye, Vitreous - Fibrosis in a female F344/N rat from a chronic study. There is advanced fibrosis in the vitreous space characterized by dense fibrous connective tissue (asterisk) with chronic inflammation (arrow); L = cataractous lens, R = detached, degenerate retina.
    Eye, Vitreous - Fibrosis in a female F344/N rat from a chronic study (higher magnification of Figure 3). The advanced fibrosis is characterized by dense fibrous connective tissue (asterisk) in the vitreous space with chronic inflammation (arrow); L = cataractous lens, R = detached degenerate retina.
    Eye, Vitreous - Fibrosis in a female F344/N rat from a chronic study. There is fibrosis (asterisk) and infiltration by migrating reactive epithelial cells (arrow) from the retinal pigment epithelium (arrowhead) in the vitreous space in the eye; R = detached and degenerate retina.
    Eye, Vitreous - Fibrosis in a male B6C3F1 mouse from a chronic study. Area of dense, mature fibrous connective tissue in the vitreous (V) and focal cartilaginous metaplasia (arrow); S = sclera.

    Author

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Ruth E. Hurley, DVM, PHD, DACVP
    Senior Veterinary Pathologist
    Huntingdon Life Sciences
    North Brunswick, NJ

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC