Harderian Gland - Hyperplasia



comment:
Harderian gland hyperplasia ( Figure 1







recommendation:
Harderian gland hyperplasia should be diagnosed and assigned a severity grade. Whether the hyperplasia is considered a primary effect or a secondary reactive change should be noted in the narrative, especially if there are treatment-related differences in incidence and/or severity.references:
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Ghanayem BI, Nyska A, Haseman JK, Bucher JR. 2002. Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice. Toxicol Sci 68:59-68. Full Text: http://toxsci.oxfordjournals.org/content/68/1/59.full
Ghanayem BI. 2007. Inhibition of urethane-induced carcinogenicity in Cyp2e1-/- in comparison to Cyp2e1+/+ mice. Toxicol Sci 95:331-339. Full Text: http://toxsci.oxfordjournals.org/content/95/2/331.full
Greaves P. 2007. Nervous system and special sense organs. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, San Diego, CA, 861-933. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Huff JE, Eastin W, Roycroft J, Eustis SL, Haseman JK. 1988. Carcinogenesis studies of benzene, methyl benzene, and dimethylbenzenes. Ann NY Acad Sci 534:427-440. Abstract: http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1988.tb30132.x/abstract
National Toxicology Program. 1997. NTP TR-461. Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Full Text: https://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr461.pdf
National Toxicology Program. 2011. NTP TR-567. Toxicology and Carcinogenesis Studies of Ginseng (CAS No. 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/34815
White V, Sinn E, Albert DM. 1990. Harderian gland pathology in transgenic mice carrying the MMTV/v-Ha-ras gene. Invest Ophthalmol Vis Sci 31:577-581. Abstract: https://pubmed.ncbi.nlm.nih.gov/2156784/
Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: October 27, 2014