Harderian Gland - Infiltration Cellular, Mononuclear Cell

comment:
Small focal clusters of inflammatory cells in the interstitium are common incidental findings in the Harderian gland of rats and mice. These infiltrates are most commonly mononuclear cells (lymphocytes) ( Figure 1

recommendation:
Harderian gland infiltrates should be diagnosed and assigned a severity grade, especially when there are treatment-related increases in incidence and/or severity. The predominant type of cell present should be indicated in the diagnosis as a modifier (e.g., Harderian gland - Infiltration cellular, Mononuclear cell). If there is an even mix of cell types (i.e., no one cell type predominates), the modifier "mixed" may be used.related links:
Harderian Gland - Inflammationreferences:
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Lambert RA, Yudkin AM. 1923. Changes in the paraocular glands accompanying the ocular lesions which result from a deficiency of vitamine A. J Exp Med 38:25-32. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19868768
National Toxicology Program. 1989. NTP TR-353. Toxicology and Carcinogenesis Studies of 2,4-Dichlorophenol (CAS No. 120-83-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6967
Papaccio G, Sellitti S, Salvatore G, Latronico MVG, Chieffi Baccari G. 1996. The Harderian gland in autoimmune diabetes of the nonobese diabetic mouse. Microsc Res Tech 34:156-165. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/8722711
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