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Lacrimal Gland - Infiltration Cellular, Mononuclear Cell

Image of infiltration cellular, mononuclear cell in the lacrimal gland from a male B6C3F1 mouse in a chronic study
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study. Variably sized interstitial foci of mononuclear cells (mainly lymphocytes) (arrow) are present in the lacrimal gland.
Figure 1 of 2
Image of infiltration cellular, mononuclear cell in the lacrimal gland from a male B6C3F1 mouse in a chronic study
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The mononuclear cells (mainly lymphocytes) are present without evidence of tissue damage.
Figure 2 of 2
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Scattered, variably sized interstitial foci of mononuclear cells (usually lymphocytes) are common in the lacrimal glands of rats and mice ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ), often increasing in incidence and severity in older animals. Increased incidences and severity of such infiltrates can also occur as treatment-related toxic effects or in other pathologic conditions.


Lacrimal gland mononuclear cell infiltrates should be diagnosed and assigned a severity grade only if there are treatment-related differences in the incidence and/or severity. Mononuclear cell infiltrates can be distinguished from inflammation by features of inflammation such as tissue destruction, hemorrhage, fibrosis, edema, and the presence of other leukocyte types.


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