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Lacrimal Gland - Infiltration Cellular, Mononuclear Cell

Image of infiltration cellular, mononuclear cell in the lacrimal gland from a male B6C3F1 mouse in a chronic study
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study. Variably sized interstitial foci of mononuclear cells (mainly lymphocytes) (arrow) are present in the lacrimal gland.
Figure 1 of 2
Image of infiltration cellular, mononuclear cell in the lacrimal gland from a male B6C3F1 mouse in a chronic study
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The mononuclear cells (mainly lymphocytes) are present without evidence of tissue damage.
Figure 2 of 2
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comment:

Scattered, variably sized interstitial foci of mononuclear cells (usually lymphocytes) are common in the lacrimal glands of rats and mice ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ), often increasing in incidence and severity in older animals. Increased incidences and severity of such infiltrates can also occur as treatment-related toxic effects or in other pathologic conditions.

recommendation:

Lacrimal gland mononuclear cell infiltrates should be diagnosed and assigned a severity grade only if there are treatment-related differences in the incidence and/or severity. Mononuclear cell infiltrates can be distinguished from inflammation by features of inflammation such as tissue destruction, hemorrhage, fibrosis, edema, and the presence of other leukocyte types.

references:

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Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850552/

National Toxicology Program. 1990. NTP TR-386. Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.