Lacrimal Gland - Inflammation



comment:
Lacrimal gland inflammation in rats and mice can result from various causes, including retrobulbar bleeding trauma, infectious agents such as sialodacryoadenitis virus in rats, and autoimmune disease.In NTP studies, there are five standard categories of inflammation: acute, suppurative, chronic, chronic-active, and granulomatous. In acute inflammation ( Figure 1




recommendation:
Lacrimal gland inflammation should be diagnosed and assigned a severity grade whenever present. The type of inflammation should be indicated in the diagnosis with an appropriate modifier (acute, chronic, etc.). The location of the inflammation within the gland (acini or duct) should be indicated in the pathology narrative. Associated lesions (e.g., fibrosis) should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative.related links:
Lacrimal Gland - Infiltration Cellular, Mononuclear Cellreferences:
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Greaves P. 2007. Nervous system and special sense organs. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, San Diego, CA, 861-933. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Krinke GJ, Schaetti PR, Krinke A. 1996. Nonneoplastic and neoplastic changes in the Harderian and lacrimal glands. In: Pathobiology of the Aging Mouse, Vol 2 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). International Life Sciences Institute Press, Washington, DC, 139-152.
Lui SH, Prendergast RA, Silverstein AM. 1987. Experimental autoimmune dacryoadenitis. I. Lacrimal disease in the rat. Invest Ophthalmol Vis Sci 28:270–275. Abstract: https://pubmed.ncbi.nlm.nih.gov/8591907/
National Toxicology Program. 1989. NTP TR-352. Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CAS No. 924-42-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6965
National Toxicology Program. 1992. NTP TR-388. Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS: 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/12227
Percy DH, Wojcinski ZW, Schunk MK. 1989. Sequential changes in the Harderian and exorbital lacrimal glands in Wistar rats infected with sialodacryoadenitis virus. Vet Pathol 26:238-245. Full Text: http://vet.sagepub.com/content/26/3/238.full.pdf
Rahimy E, Pitcher JD III, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. 2010. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol 177:744-753. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913359/
Web page last updated on: October 28, 2014