Lacrimal Gland - Metaplasia, Harderian

comment:
Clusters of tubules lined by cuboidal cells with pale, foamy to vacuolated cytoplasm (resembling Harderian gland alveoli) can occur in the lacrimal glands of rats and mice, especially rats ( Figure 1

recommendation:
This finding should be diagnosed as "lacrimal gland - metaplasia, Harderian" and assigned a severity grade. It should be diagnosed only if there are treatment-related differences in incidence and/or severity. "Ectopic Harderian gland" and "ectopic tissue" are considered inappropriate terms because they suggest a developmental anomaly.references:
Cornell-Bell AH, Sullivan DA, Allansmith MR. 1985. Gender-related differences in morphology of the lacrimal gland. Invest Ophthalmol Vis Sci 26:1170-1175. Abstract: https://pubmed.ncbi.nlm.nih.gov/4019110/
Gaertner DJ, Lindsay JR, Stevens JO. 1988. Cytomegalic changes and "inclusions" in lacrimal glands of laboratory rats. Lab Anim Sci 38:79-82. Abstract: http://ebm.sagepub.com/content/101/1/164.short
Geiss V, Yoshitomi K. 1999. Eyes. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 471-489. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Krinke AL, Schaetti PR, Krinke GJ. 1994. Changes in the major ocular glands. In: Pathobiology of the Aging Rat, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). International Life Sciences Institute Press, Washington, DC, 109-119.
Krinke GJ, Schaetti PR, Krinke A. 1996. Nonneoplastic and neoplastic changes in the Harderian and lacrimal glands. In: Pathobiology of the Aging Mouse, Vol 2 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). International Life Sciences Institute Press, Washington, DC, 139-152.
National Toxicology Program. 1990. NTP TR-376. Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/8892
Percy DH, Wojcinski ZW, Schunk MK. 1989. Sequential changes in the Harderian and exorbital lacrimal glands in Wistar rats infected with sialodacryoadenitis virus. Vet Pathol 26:238-245. Full Text: http://vet.sagepub.com/content/26/3/238.full.pdf
Sashima M, Hatakeyama S, Satoh M, Suzuki A. 1989. Harderianization is another sexual dimorphism of rat exorbital lacrimal gland. Acta Anat 135:303-306. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/2801002
Tier H. 1949. On the sizes of the nuclei in the glandula infraorbitalis of the white rat. Acta Pathol Microbiol Scand 26:620-625. Abstract: http://onlinelibrary.wiley.com/doi/10.1111/j.1699-0463.1949.tb00761.x/abstract
Walker R. 1958. Age changes in the rat’s extraorbital lacrimal gland. Anat Rec 132:49-69. Abstract: http://onlinelibrary.wiley.com/doi/10.1002/ar.1091320104/abstract
Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: October 28, 2014