Kidney - Amyloid

Kidney, Glomerulus - Amyloid in a female B6C3F1 mouse from a chronic study. Glomeruli contain a pale, amorphous, eosinophilic material identified as amyloid.
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Kidney, Glomerulus - Amyloid in a female B6C3F1 mouse from a chronic study. Increased amounts of pale-staining eosinophilic glomerular deposits of amyloid are present.
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Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study. Positive Congo red staining of glomerular amyloid deposits are present in the glomeruli.
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Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study (same mouse as in Figure 3). Congo red staining with polarization of amyloid deposits shows the characteristic apple-green birefringence.
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Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study (higher magnification of Figure 4). Congo red staining with polarization shows the characteristic apple-green birefringence of amyloid deposits.
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comment:
Amyloid deposition is a spontaneous and age-related disease that occasionally can be related to test item administration. It is commonly noted in some strains of mouse, particularly the CD-1 mouse, but is rarely reported or observed in the rat. Amyloid is most commonly noted as an extracellular deposition of pale, homogeneous, slightly eosinophilic material in renal glomeruli ( Figure 1





recommendation:
Amyloid should be diagnosed and graded. The location of the amyloid deposits should be indicated in the diagnosis by using a site modifier. Any secondary lesions, such as necrosis or degeneration, should not be diagnosed separately unless warranted by severity. Secondary lesions should, however, be described in the pathology narrative.related links:
Kidney - Hyaline GlomerulopathyKidney - Glomerulonephritis
Kidney - Glomerulosclerosis
Kidney, Papilla - Necrosis
references:
Frith CH, Chandra M. 1991. Incidence, distribution, and morphology of amyloidosis in Charles Rivers CD-1 mice. Toxicol Pathol 19:123-127. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1771365
Higuchi K, Naiki H, Kitagawa K, Hosokawa M, Takeda T. 1991. Mouse senile amyloidosis. ASSAM amyloidosis in mice presents universally as a systemic age-associated amyloidosis. Virchows Arch B Cell Pathol Incl Mol Pathol 60:231-238. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1681611
Wojcinski ZW, Albassam MA, Smith GS. 1992. Hyaline glomerulopathy in B6C3F1 mice. Toxicol Pathol 19:224-229.
Web page last updated on: October 28, 2014