Urinary System

Kidney - Amyloid

    Narrative
    Kidney, Glomerulus - Amyloid in a female B6C3F1 mouse from a chronic study. Glomeruli contain a pale, amorphous, eosinophilic material identified as amyloid.
    Kidney, Glomerulus - Amyloid in a female B6C3F1 mouse from a chronic study. Increased amounts of pale-staining eosinophilic glomerular deposits of amyloid are present.
    Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study. Positive Congo red staining of glomerular amyloid deposits are present in the glomeruli.
    Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study (same mouse as in Figure 3). Congo red staining with polarization of amyloid deposits shows the characteristic apple-green birefringence.
    Kidney, Glomerulus - Amyloid in a B6C3F1 mouse from a chronic study (higher magnification of Figure 4). Congo red staining with polarization shows the characteristic apple-green birefringence of amyloid deposits.
    Kidney, Papilla - Amyloid in a B6C3F1 mouse from a chronic study (same mouse as in Figure 3). Congo red staining with polarization of amyloid deposits in the renal papilla shows the characteristic apple-green birefringence.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC