Kidney - Crystals

Kidney, Renal tubule - Crystals in a male B6C3F1 mouse from a chronic study. There are crystals (arrows) within tubule lumens.
Figure 1 of 3

Kidney, Renal tubule - Crystals in a male rat from an acute study. Crystal deposition with secondary inflammation is present in the renal papilla.
Figure 2 of 3
comment:
Crystals can occur in any of the renal tubule segments or renal pelvis ( Figure 1


recommendation:
Crystals should be diagnosed and given a severity grade whenever present. The location of the crystals should be included in the diagnosis as a site modifier (e.g., renal tubule or pelvis). The features of the crystals should be discussed in the pathology narrative. Secondary lesions, such as inflammation, should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative.references:
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Hagiwara A, Asakawa E, Kurata Y, Sano M, Hirose M, Ito N. 1992. Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats. Toxicol Pathol 20:197-204. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1475580
Yarlagadda SG, Perazella MA. 2008. Drug-induced crystal nephropathy: An update. Expert Opin Drug Safety 7:147-158. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18324877
Web page last updated on: October 28, 2014