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Kidney, Glomerulus - Metaplasia

Image of glomerulus metaplasia in the kidney from a female B6C3F1 mouse in a subchronic study
Kidney, Glomerulus - Normal in a female B6C3F1 mouse from a subchronic study. The parietal epithelial cells lining the glomerulus of the female mouse are normally flattened (arrow).
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Image of glomerulus metaplasia in the kidney from a female B6C3F1 mouse in a chronic study
Kidney, Glomerulus - Metaplasia in a female B6C3F1 mouse from a chronic study. Metaplasia is characterized by a change from the flattened parietal epithelium to cuboidal epithelium (arrow).
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comment:

In the mouse, sexual dimorphism of the glomerular parietal epithelium of Bowman’s capsule exists. The female parietal epithelial cells are typically flattened ( Figure 1image opens in a pop-up window ) and the male parietalepithelium can be both cuboidal and flattened. In glomerular metaplasia, caused by administration of some androgenic compounds, the female parietal epithelium becomes cuboidal, or male-like ( Figure 2image opens in a pop-up window ).

recommendation:

Glomerular metaplasia of Bowman’s capsule should be diagnosed and given a severity grade.

references:

Seely JC. 1999. Kidney. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 207-234.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.