Kidney - Glomerulonephritis

Kidney - Glomerulonephritis in a female B6C3F1 mouse from a chronic study. Glomerulonephritis is characterized by enlarged glomeruli with increased cellularity and mesangial expansion.
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Kidney - Glomerulonephritis in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1). Higher magnification of glomerulonephritis in a glomerulus.
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Kidney - Glomerulonephritis in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1). Higher magnification of the mesangial expansion and increased cellularity.
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comment:
Glomerulonephritis (GN) results from acute to chronic glomerular injury resulting in glomeruli that appear enlarged and hypercellular with an increase in mesangial matrix ( Figure 1


recommendation:
Glomerulonephritis should be diagnosed and given a severity grade. The type and extent of glomerulonephritis should be indicated in the pathology narrative.related links:
Kidney - AmyloidKidney - Glomerulosclerosis
Kidney - Hyaline Glomerulopathy
Kidney - Nephropathy, Chronic Progressive
references:
Bruijn JA, de Heer E, Hoedemaeker PJ. 1998. Immune mechanisms in injury to glomeruli and tubulointerstitial tissue. In: Monographs on Pathology of Laboratory Animals: Urinary System, 2nd ed (Jones TC, Hard GC, Mohr U, eds). Springer, Berlin, 199-224. Abstract: http://www.ilsi.org/publications/urinarysystem.pdf
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Web page last updated on: October 28, 2014