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Kidney - Glomerulosclerosis

Image of glomerulosclerosis in the kidney from a male Wistar Han rat in a chronic study
Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Several glomeruli (arrows) associated with chronic progressive nephropathy have an increase in eosinophilic matrix and contraction of the glomerular tuft.
Figure 1 of 2
Image of glomerulosclerosis in the kidney from a male Wistar Han rat in a chronic study
Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Affected glomeruli often have adhesions (arrow) between the glomerular tuft and Bowman�s capsule.
Figure 2 of 2
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comment:

Glomerulosclerosis is a consequence of chronic degenerative changes in the glomerulus and is rarely observed as a primary lesion in NTP studies. Characteristic features include shrinkage and contraction of the glomerular tuft and replacement of the mesangium by fibrosis ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). The presence of amyloid deposits must be ruled out because of similar morphologic features. Glomerulosclerosis may be focal, segmental, or global.

recommendation:

Primary glomerulosclerosis should be diagnosed and given a severity grade. When a component of the spectrum of changes associated with chronic progressive nephropathy or part of a secondary response to some other primary renal disease, glomerulosclerosis should not be diagnosed separately but should be described in the pathology narrative.

references:

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.