Urinary System

Kidney - Glomerulosclerosis

Narrative

Comment:

Glomerulosclerosis is a consequence of chronic degenerative changes in the glomerulus and is rarely observed as a primary lesion in NTP studies. Characteristic features include shrinkage and contraction of the glomerular tuft and replacement of the mesangium by fibrosis (Figure 1 and Figure 2). The presence of amyloid deposits must be ruled out because of similar morphologic features. Glomerulosclerosis may be focal, segmental, or global.

Recommendations:

Primary glomerulosclerosis should be diagnosed and given a severity grade. When a component of the spectrum of changes associated with chronic progressive nephropathy or part of a secondary response to some other primary renal disease, glomerulosclerosis should not be diagnosed separately but should be described in the pathology narrative.

References:

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735

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Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Several glomeruli (arrows) associated with chronic progressive nephropathy have an increase in eosinophilic matrix and contraction of the glomerular tuft.

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<p>Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Several glomeruli (arrows) associated with chronic progressive nephropathy have an increase in eosinophilic matrix and contraction of the glomerular tuft.</p>

Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Several glomeruli (arrows) associated with chronic progressive nephropathy have an increase in eosinophilic matrix and contraction of the glomerular tuft.

<p>Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Affected glomeruli often have adhesions (arrow) between the glomerular tuft and Bowman�s capsule.</p>

Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Affected glomeruli often have adhesions (arrow) between the glomerular tuft and Bowman�s capsule.

Authors and Reviewers

Authors

John Curtis Seely, DVM, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Kendall S. Frazier, DVM, PhD, DACVP, DABT
Director, Cellular and Molecular Pathology, Safety Assessment
GlaxoSmithKline
King of Prussia, PA

Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
Expert Consultant
Tairua, New Zealand

Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
Staff Scientist, NTP Pathologist
NTP Pathology Group
National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC