Kidney - Glomerulosclerosis
comment:Glomerulosclerosis is a consequence of chronic degenerative changes in the glomerulus and is rarely observed as a primary lesion in NTP studies. Characteristic features include shrinkage and contraction of the glomerular tuft and replacement of the mesangium by fibrosis ( Figure 1 and Figure 2 ). The presence of amyloid deposits must be ruled out because of similar morphologic features. Glomerulosclerosis may be focal, segmental, or global.
recommendation:Primary glomerulosclerosis should be diagnosed and given a severity grade. When a component of the spectrum of changes associated with chronic progressive nephropathy or part of a secondary response to some other primary renal disease, glomerulosclerosis should not be diagnosed separately but should be described in the pathology narrative.
related links:Kidney - Amyloid
Kidney - Glomerulonephritis
Kidney - Hyaline Glomerulopathy
Kidney - Inflammation
Kidney - Nephropathy, Chronic Progressive
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Web page last updated on: October 28, 2014