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Kidney, Interstitium - Infiltration, Cellular

Image of infiltration cellular, lymphocyte in the kidney from a  rat
Kidney, Interstitium - Infiltration, Cellular, Lymphocyte in a rat. There are relatively small numbers of lymphocytes in the renal cortical interstitium, with little to no tissue damage.
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comment:

Cellular infiltrates are routinely observed in the kidneys of rodents ( Figure 1image opens in a pop-up window ). The infiltrating cells are typically lymphoid or mononuclear cells, but other inflammatory cell types may comprise the infiltrates. These infiltrates generally increase with age. In many cases, they represent a background finding that has little pathologic significance. Cellular infiltration must be differentiated from inflammation. In general, cellular infiltration is diagnosed when the number of inflammatory cells is relatively low and no other indicators of inflammation (e.g., edema, hemorrhage, tissue damage) accompany the cells.

recommendation:

Cellular infiltration should be diagnosed when it is treatment related. If it is not treatment related, its diagnosis is left to the discretion of the pathologist. If diagnosed, the cell type should be indicated in the diagnosis as a modifier (e.g., Kidney, Interstitium - Infiltration, Cellular, Lymphocyte).

related links:

Kidney - Inflammation

references:

Seely JC. 1999. Kidney. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 207-234.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.