Kidney - Mineralization

Kidney - Mineralization in a male F344 rat from an acute study. Spontaneous mineralization of cortical tubules is present.
Figure 1 of 3

Kidney - Mineralization in a female Sprague-Dawley rat from an acute study. Mineralization is commonly observed in the area of the outer stripe and inner stripe of the outer medulla.
Figure 2 of 3
comment:
Mineralization is more commonly associated with spontaneous and minute background findings of basophilic deposits in the renal cortex, medulla,or papilla of rats and mice ( Figure 1


recommendation:
Mineralization should be diagnosed and graded. If small deposits of focal mineralization are recognized as a spontaneous background finding, they need not be diagnosed and the pathologist should use his or her judgment in deciding whether or not they are prominent enough to warrant diagnosis. When diagnosed, the pattern of the mineralization (e.g., linear papillary mineralization, focal medullary mineralization) should be described in the pathology narrative.references:
Gopinath C, Prentice DE, Lewis DJ. 1987. Atlas of Experimental Toxicological Pathology. MTP Press, Lancaster, UK, 77-88.
Ritskes-Hoitinga J, Beynen AC. 1992. Nephrocalcinosis in the rat: A literature review. Prog Food Nutr Sci 16:85-124. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1620876
Web page last updated on: October 28, 2014