Kidney - Nephroblastematosis

Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. An area of dense basophilic cellularity can be seen in the renal cortex.
Figure 1 of 4

Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. The cells are deeply basophilic and uniform in morphology. They are infiltrating between renal tubules, and no organoid differentiation of the lesion can be recognized.
Figure 2 of 4

Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. At higher magnification, the cells in nephroblastematosis have indistinct cell margins and cytoplasm, round to oval nuclei with stippled chromatin, and often a prominent nucleolus.
Figure 3 of 4

Kidney - Infiltration, Cellular, Mononuclear in a female Harlan Sprague-Dawley rat from a subchronic study. This higher magnification of mononuclear cell infiltration, characterized by a heterogeneous population of cells in the kidney and small blood vessels, is for comparison with Figures 1 - 3.
Figure 4 of 4
comment:
Nephroblastematosis can be a spontaneous lesion and is the presumptive precursor lesion of nephroblastoma. On low power, nephroblastematosis appears as an area of densely basophilic cellularity ( Figure 1



recommendation:
Nephroblastematosis should be diagnosed whenever present and given a severity grade.references:
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Mesfin GM. 1999. Intralobar nephroblastemosis: Precursor lesion of nephroblastoma in the Sprague-Dawley rat. Vet Pathol 36:379-390. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10490205
Web page last updated on: October 28, 2014