Urinary System

Kidney - Nephroblastematosis

    Narrative
    Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. An area of dense basophilic cellularity can be seen in the renal cortex.
    Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. The cells are deeply basophilic and uniform in morphology. They are infiltrating between renal tubules, and no organoid differentiation of the lesion can be recognized.
    Kidney - Nephroblastematosis in a female Harlan Sprague-Dawley rat from a subchronic study. At higher magnification, the cells in nephroblastematosis have indistinct cell margins and cytoplasm, round to oval nuclei with stippled chromatin, and often a prominent nucleolus.
    Kidney - Infiltration, Cellular, Mononuclear in a female Harlan Sprague-Dawley rat from a subchronic study. This higher magnification of mononuclear cell infiltration, characterized by a heterogeneous population of cells in the kidney and small blood vessels, is for comparison with Figures 1 - 3.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC