Urinary System

Kidney - Nephropathy, Obstructive

    Narrative
    Kidney - Nephropathy, Obstructive in a female F344/N rat from a chronic study. Dilated tubules extending from the renal papilla into the cortex are characteristic of obstructive nephropathy.
    Kidney - Nephropathy, Obstructive in a female Harlan Sprague-Dawley rat from a subchronic study. This more severe case of obstructive nephropathy is characterized by dilated renal tubules and collecting ducts.
    Kidney - Nephropathy, Obstructive in a female Harlan Sprague-Dawley rat from a subchronic study. There are cortical tubule and ductal changes, including dilation and tubule basophilia.
    Kidney - Nephropathy, Obstructive in a female Harlan Sprague-Dawley rat from a subchronic study (same animal as in Figure 3). Tubule changes associated with obstructive nephropathy are shown.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC