Kidney, Papilla - Necrosis

Kidney, Papilla - Necrosis in a male F344/N rat from a chronic study. Early necrosis of the papilla shows loss of cellular detail and staining affinity.
Figure 1 of 4

Kidney, Papilla - Necrosis in a male F344/N rat from a subchronic study. A portion of the necrotic renal papilla is sloughed off into the renal pelvis.
Figure 2 of 4

Kidney, Papilla - Necrosis in a female B6C3F1 mouse from a chronic study. There is a large area of papillary necrosis with a prominent peripheral zone of inflammation.
Figure 3 of 4
comment:
Renal papillary necrosis is a specific entity involving the tip of the renal papilla. Early stages involve loss of cellular definition and loss of staining affinity in the area of the papillary tip ( Figure 1



recommendation:
Necrosis of the renal papilla should be diagnosed and given a severity grade. The study pathologist should use his or her judgment in deciding whether or not secondary lesions, such as inflammation, associated with papillary necrosis are prominent enough to warrant a separate diagnosis.references:
Brix AE. 2002. Renal papillary necrosis. Toxicol Pathol 30:672-674. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12512867
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Greaves P. 2012. Histopathology of Preclinical Toxicity Studies, 4th ed. Elsevier, Amsterdam, 574-576. Abstract: http://www.sciencedirect.com/science/book/9780444538567
Web page last updated on: October 28, 2014