Urinary System

Kidney, Papilla - Necrosis

    Narrative
    Kidney, Papilla - Necrosis in a male F344/N rat from a chronic study. Early necrosis of the papilla shows loss of cellular detail and staining affinity.
    Kidney, Papilla - Necrosis in a male F344/N rat from a subchronic study. A portion of the necrotic renal papilla is sloughed off into the renal pelvis.
    Kidney, Papilla - Necrosis in a female B6C3F1 mouse from a chronic study. There is a large area of papillary necrosis with a prominent peripheral zone of inflammation.
    Kidney, Papilla - Necrosis in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3). Acute necrosis and inflammatory infiltrate are present.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC