Urinary System

Kidney, Renal Tubule - Accumulation, Hyaline Droplet

    Narrative
    Kidney, Renal tubule - Hyaline droplets in a male F344/N rat from a subchronic study. Normal-appearing small hyaline droplets are present in renal tubule epithelial cells.
    Kidney, Renal tubule - Hyaline droplets in a male rat from a subchronic study. The cytoplasmic staining pattern of normal hyaline droplets is presented (Mallory-Heidenhain stain).
    Kidney, Renal tubule - Hyaline droplets in a male F344/N rat from a subchronic study (higher magnification of Figure 2). Several droplet-congested, normal, renal tubule epithelial cells are shown (Mallory-Heidenhain stain).
    Kidney, Renal tubule - Accumulation, Hyaline droplet in a male F344/N rat from a subchronic study. Increased number and size of hyaline droplets associated with chemically induced increase in alpha 2u-globulin.
    Kidney, Renal tubule - Accumulation, Hyaline droplets in a male F344/N rat from a subchronic study. The appearance of enlarged and crystalline-shaped droplets is associated with chemically induced increase in alpha 2u-globulin (Mallory-Heidenhain stain).
    Kidney, Renal tubule - Accumulation, Hyaline droplets in a B6C3F1 mouse in a subchronic study. Hyaline droplets are associated with histiocytic sarcoma.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC