Kidney, Renal Tubule - Cytoplasmic Alteration

Kidney, Renal tubule - Normal in a male B6C3F1 mouse from a chronic study. Numerous clear cytoplasmic vacuoles are present in renal tubule cells.
Figure 1 of 2
comment:
Variable cytoplasmic vacuolation in outer cortical tubules of certain strains of male mice is a normal finding ( Figure 1

recommendation:
Cytoplasmic vacuolation that is present as a normal background finding in male mice does not have to be diagnosed. If a decrease in cytoplasmic vacuoles is seen following treatment in male mice (compared with controls), then this finding should be diagnosed as "cytoplasmic alteration" and given a severity grade.related links:
Kidney, Renal Tubule - Vacuolation, Cytoplasmicreferences:
Ormos J, Sztriha L, Bóti ZS, Kuthy E. 1975. Electron microscopic and cytochemical study of the vacuoles of regenerating renal tubular cells. Br J Exp Pathol 55:477-483. Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072774/
Seely JC. 1999. Kidney. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 207-234. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: October 28, 2014