Kidney, Renal Tubule - Dilation

Kidney, Renal tubule - Dilation in a male B6C3F1 mouse from a chronic study. Dilated tubules are noted as tracts running through the cortex and outer medulla.
Figure 1 of 4

Kidney, Renal tubule - Dilation in a male F344/N rat from a chronic study. Tubule dilation is present throughout the outer stripe of the outer medulla, extending into the cortex.
Figure 2 of 4

Kidney, Renal tubule - Dilation in a male B6C3F1 mouse from a chronic study. Slight tubule dilation is associated with degeneration and necrosis.
Figure 3 of 4
comment:
Renal tubule dilation may occur anywhere along the nephron or collecting duct system. It may occur in focal areas or as tracts running along the entire length of kidney sections ( Figure 1
Renal tubule dilation may occur from xenobiotic administration, secondary mechanisms, or an unknown pathogenesis (see Kidney - Nephropathy, Obstructive) ( Figure 2



recommendation:
Renal tubule dilation should be diagnosed and given a severity grade. The location of tubule dilation should be included in the diagnosis as a site modifier. The pathologist should use his or her judgment in deciding whether or not secondary tubule dilation is prominent enough to warrant a separate diagnosis.references:
Greaves P. 2012. Histopathology of Preclinical Toxicity Studies, 4th ed. Elsevier, Amsterdam, 560. Abstract: http://www.sciencedirect.com/science/book/9780444538567
Lameire N. 2005. The pathophysiology of acute renal failure. Crit Care Clinics 21:197-210.
Web page last updated on: October 28, 2014