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  • Kidney, Renal Tubule - Hyperplasia, Amphophilic-Vacuolar

    Image of renal tubule hyperplasia, amphophilic-vacuolar in the kidney from a female F344/N rat in a chronic study
    Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar in a female F344/N rat from a chronic study. There is a small focus of hyperplastic tubule cells with amphophilic and vacuolated cytoplasm.
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    Amphophilic-vacuolar (A-V) hyperplasia is a small proliferative lesion associated with variable amphophilic cytoplasmic staining and intra- and/or extracellular vacuoles ( Figure 1image opens in a pop-up window ). As with atypical tubule hyperplasia, in A-V hyperplasia the proliferating cells are considered to be within the confines of a single renal tubule. If the cells proliferate beyond the confines of a single tubule, the lesion is considered a neoplasm (adenoma or carcinoma). A-V hyperplasia has been postulated to be a familial condition in rats, which may progress to tumors.


    Amphophilic-vacuolar hyperplasia should be diagnosed as "Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar" and given a severity grade.


    Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.

    Hard GC, Seely JC, Kissling GE, Betz LJ. 2012. Spontaneous occurrence of a distinctive renal tubule phenotype in rat carcinogenicity studies conducted by the National Toxicology Program. Toxicol Pathol 36:388-396.

    Kudo K, Hoshiya T, Nakazawa T, Saito T, Shimoyama N, Suzuki I, Tamura K, Seely JC. 2012. Spontaneous renal tumors suspected of being familial in Sprague-Dawley rats. J Toxicol Pathol 25:277-280.