Kidney, Renal Tubule - Hyperplasia, Amphophilic-Vacuolar
comment:
Amphophilic-vacuolar (A-V) hyperplasia is a small proliferative lesion associated with variable amphophilic cytoplasmic staining and intra- and/or extracellular vacuoles ( Figure 1
recommendation:
Amphophilic-vacuolar hyperplasia should be diagnosed as "Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar" and given a severity grade.references:
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Hard GC, Seely JC, Kissling GE, Betz LJ. 2012. Spontaneous occurrence of a distinctive renal tubule phenotype in rat carcinogenicity studies conducted by the National Toxicology Program. Toxicol Pathol 36:388-396. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18441261
Kudo K, Hoshiya T, Nakazawa T, Saito T, Shimoyama N, Suzuki I, Tamura K, Seely JC. 2012. Spontaneous renal tumors suspected of being familial in Sprague-Dawley rats. J Toxicol Pathol 25:277-280. Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517924/
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