Kidney, Renal Tubule - Hyperplasia, Amphophilic-Vacuolar
comment:Amphophilic-vacuolar (A-V) hyperplasia is a small proliferative lesion associated with variable amphophilic cytoplasmic staining and intra- and/or extracellular vacuoles ( Figure 1 ). As with atypical tubule hyperplasia, in A-V hyperplasia the proliferating cells are considered to be within the confines of a single renal tubule. If the cells proliferate beyond the confines of a single tubule, the lesion is considered a neoplasm (adenoma or carcinoma). A-V hyperplasia has been postulated to be a familial condition in rats, which may progress to tumors.
recommendation:Amphophilic-vacuolar hyperplasia should be diagnosed as "Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar" and given a severity grade.
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Hard GC, Seely JC, Kissling GE, Betz LJ. 2012. Spontaneous occurrence of a distinctive renal tubule phenotype in rat carcinogenicity studies conducted by the National Toxicology Program. Toxicol Pathol 36:388-396. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18441261
Kudo K, Hoshiya T, Nakazawa T, Saito T, Shimoyama N, Suzuki I, Tamura K, Seely JC. 2012. Spontaneous renal tumors suspected of being familial in Sprague-Dawley rats. J Toxicol Pathol 25:277-280. Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517924/
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