Kidney, Renal Tubule - Hypertrophy

Kidney, Renal tubule - Hypertrophy in a male F344/N rat from a chronic study. These hypertrophied tubular epithelial cells with an increased amount of amorphous, eosinophilic cytoplasm and small, round, dense nuclei are associated with chronic progressive nephropathy.
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comment:
Renal tubule hypertrophy is characterized by enlarged tubule epithelial cells that have variable tinctorial staining. Typically, the tubule is lined by a single layer of epithelial cells, and the numbers of epithelial cells are not increased. The cytoplasm of hypertrophic cells is usually amorphous and brightly eosinophilic, while nuclei appear small, round and dense ( Figure 1

recommendation:
Renal tubule hypertrophy should be diagnosed and given a severity grade. Hypertrophy as a component of chronic progressive nephropathy should not be diagnosed separately but should be considered a component of chronic progressive nephropathy.references:
Ellison DH, Velazquez H, Wright FS. 1989. Adaptation of the distal tubule of the rat. Structural and functional effects of dietary salt intake and chronic diuretic infusion. J Clin Invest 83:113-126. Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303651/
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Web page last updated on: October 28, 2014