Kidney, Renal Tubule - Necrosis

Kidney, Renal tubule - Necrosis in a female B6C3F1 mouse from a chronic study. Diffuse tubule necrosis appears as lighter-staining, more eosinophilic tubules.
Figure 1 of 2
comment:
The diagnosis of necrosis encompasses death of individual cells, to focal or multifocal areas of tubule necrosis, to larger confluent areas of renal parenchyma necrosis ( Figure 1

recommendation:
Necrosis should be diagnosed and given a severity grade. Necrosis associated with the presence of a tumor should not be diagnosed but should be described in the pathology narrative. Secondary changes, such as regeneration and inflammation, should not be diagnosed separately, unless warranted by severity, but should be described in the narrative. Renal tubular necrosis must be differentiated from artifact.references:
<p>Davis MA, Ryan DH. 1998. Apoptosis in the kidney. Toxicol Pathol 26:810-825.</p> Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9864100
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Harriman JF, Schnellmann RG. 2005. Mechanisms of renal cell death. In: Toxicology of the Kidney (Tarloff JB, Lash LH, eds). CRC Press, Boca Raton, FL, 245-297.
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