Kidney, Renal Tubule - Regeneration

comment:
Renal tubule regeneration occurs as a reparative response to previous degeneration and/or necrosis of renal tubular epithelium. It is one of the most common test-article-related lesions observed in the kidney. Regeneration is characterized by a spectrum of histologic changes, including cytoplasmic basophilia, karyomegaly, and nuclear crowding along the affected tubule segment ( Figure 1

recommendation:
Regeneration should be diagnosed and given a severity grade. Tubule regeneration accompanying CPN-related regeneration should not be diagnosed separately but should be included in the diagnosis of CPN. If necrosis is significant, it may be diagnosed concurrently. The difference between hyperplasia and regeneration can be problematic, and the pathologist must use his or her judgment in differentiating these lesions.references:
Cuppage FE, Tate A. 1967. Repair of the nephron following injury with mercuric chloride. Am J Pathol 51:405-429. Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965336/
Dube PH, Almanzar MM, Frazier KS, Paredes AI. 2004. Osteogenic protein-1 (rhOP-1) treatment induces tubular regeneration in the acute and chronic phases of the rat remnant kidney model. Toxicol Pathol 32:382-394.
Toback FG. 1992. Regeneration after acute tubular necrosis. Kidney Int 41:226-246. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1593859
Van de Water B, Imamdi R, de Graauw M. 2005. Signal transduction in renal cell repair and regeneration. In: Toxicology of the Kidney, 3rd ed (Tarloff JB, Lash LH, eds). CRC Press, Boca Raton, FL, 299341.
Web page last updated on: October 28, 2014