Kidney, Renal Tubule - Vacuolation, Cytoplasmic

comment:
Cytoplasmic vacuolation is characterized by the presence of clear vacuoles in renal tubule epithelium in the absence of any morphologic changes associated with degeneration ( Figure 1
recommendation:
Normally, male mice have variable cortical tubule cytoplasmic vacuolationand do not have to be diagnosed (see Kidney, Renal Tubule -Cytoplasmic Alteration).In male mice, cytoplasmic vacuolation should be diagnosed only when the number and/or size of vacuoles is greater than that of the concurrent controls.Cytoplasmic vacuolation in female mice and male and female rats should be diagnosed whenever present. This diagnosis should be reserved for those cases where the vacuoles are present in the absence of other morphologic features of degeneration. The tubule location and portion of the kidney affected should be described in the pathology narrative. Whenever it is diagnosed, cytoplasmic vacuolationshould be graded. Artifactual vacuolation should not be diagnosed.related links:
Kidney, Renal Tubule -Cytoplasmic Alterationreferences:
Bendele A, Seely J, Richey C, Sennello G, Shopp G. 1998. Short communication: Renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins. Toxicol Sci 42:152-157. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9579027
Johson RC, Dovey-Hartman BJ, Syed J, Leach MW, Frank DW, Sinha DP, Mirro EJ, Little JM, Halliwell WH. 1998. Vacuolation in renal tubular epithelium of Cd-1 mice: An incidental finding. Toxicol Pathol 26:789-792. Full Text: http://tpx.sagepub.com/content/26/6/789.full.pdf
Khan KNM, Alden CL. 2002. Kidney. In: Handbook of Toxicologic Pathology, 2nd ed (Haschek WG, Rousseaux CG, Wallig MA, eds). Academic Press, San Diego, 255-336. Abstract: http://www.sciencedirect.com/science/book/9780123302151
Monserrat AJ, Chandler AE. 1975. Effects of repeated injections of sucrose in the kidney: Histologic, cytochemical and functional studies in an animal model. Virchows Arch B 19:77-91. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/809924
Nonoyama T, Fukuda R. 2008. Drug-induced phospholipidosis - pathological aspects and its prediction. J Toxicol Pathol 21:9-24. Abstract: https://www.jstage.jst.go.jp/article/tox/21/1/21_1_9/_article
Rees JA, Old SI, Rowlands PC. 1997. An ultrastructural, histochemistry, and light microscopy study of the early development of renal proximal tubular vacuolation after a single administration of the contrast enhancement medium "Iotrolan." Toxicol Pathol 25:158-164. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9125774
Web page last updated on: October 23, 2014