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Ureter - Dilation

Image of dilation in the ureter from a male mouse
Greatly dilated ureter (arrow) of probable familial origin from a male mouse.
Figure 1 of 1
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comment:

Dilation of the ureter (synonym: hydroureter) is most commonly associated with cases of obstruction. Often it can be seen grossly with dilation of the urinary bladder and renal pelvis. It can be either unilateral or bilateral ( Figure 1image opens in a pop-up window ). In rats, congenital cases are more prevalent on the right side. A strain of mouse (NON/Shi) and a strain of rat (SD/cShi) have been developed that have spontaneous hydroureter and hydronephrosis and can be induced to develop proliferative lesions of the renal pelvic urothelium.

recommendation:

Dilation of the ureter should be diagnosed and assigned a severity grade. If ureter dilation is treatment related, the study pathologist should describe whether the lesion is unilateral or bilateral.

references:

Anver M, Haines D, Swing D, Ward J. 2001. Transitional cell proliferative lesions of the ureter with hydronephrosis in B6D2F1/Cr mice. Vet Pathol 38:5.

Bendele M. 1998. Urologic syndrome, mouse. In: Monographs on Pathology of Laboratory Animals: Urinary System, 2nd ed (Jones TC, Hard GC, Mohr U, eds). Springer, Berlin, 456-462.
Abstract: http://www.ilsi.org/publications/urinarysystem.pdf

Maronpot RR. 1998. Spontaneous hydronephrosis, rat. In: Monographs on Pathology of Laboratory Animals: Urinary System, 2nd ed (Jones TC, Hard GC, Mohr U, eds). Springer, Berlin, 306-309.
Abstract: http://www.ilsi.org/publications/urinarysystem.pdf

Murai T, Mori S, Hosono M, Takeuchi Y, Ohara T, Makino S, Takeda R, Hayashi Y, Fukushima S. 1991. Renal pelvic carcinoma which shows metastatic potential to distant organs induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in NON/Shi mice. Jpn J Cancer Res 82:1371-1377.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1778760

Murai T, Mori S, Machino S, Hosono M, Takeuchi Y, Ohara T, Makino S, Takeda R, Hayashi Y, Iwata H, Yamamoto S, Ito H, Fukushima S. 1993 Induction of renal pelvic carcinoma by phenacetin in hydronephrosis-bearing rats of the SD/cShi strain. Cancer Res 53:4218-4223.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/8364917

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Web page last updated on: January 02, 2014

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.