Urinary System

Urinary Bladder - Metaplasia

    Narrative
    Diffuse squamous metaplasia and keratinization of hyperplastic urothelium from a female F344/N rat in a subchronic interim study.
    Squamous metaplasia and keratinization from a female F344/N rat in a 40-week interim study.
    Squamous metaplasia with and without keratinization, from a female F344/N rat in a subchronic interim study.
    Mucinous metaplasia (arrows) characterized by mucinous cells in areas of urothelial hyperplasia, from a female F344/N rat in a chronic study.

    Authors

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska,  DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University
    Timrat Israel

    Reviewers

    Samuel M Cohen, PHD, MD
    Professor
    Havlik-Wall Professor of Oncology
    Director of Pathology Residency Program
    Nebraska Medical Center
    Omaha, NE

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC