U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Urinary Bladder - Ulcer

Image of ulcer in the urinary bladder from a male B6C3F1 mouse in a chronic study
A focal ulcer of the urothelium, with inflammation of the underlying submucosa and muscularis layers, from a male B6C3F1 mouse in a chronic study.
Figure 1 of 2
Image of ulcer in the urinary bladder from a male F344/N rat in a chronic study
A focal ulcer with extensive necrosis and acute inflammation from a male F344/N rat in a chronic study.
Figure 2 of 2
next arrow

comment:

Ulcers may result from a number of etiologies, such as direct chemical exposure or as secondary lesions associated with inflammation, calculi, or tumors. Ulcers usually progress from urothelial erosions/necrosis and extend through the width of the urothelium, resulting in subepithelial hemorrhage and inflammation ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). The severity of the inflammation depends on the size and the chronicity of the ulcer. Acute ulceration may develop rapidly. Regenerative hyperplasia and/or fibrosis may be observed in chronic cases.

recommendation:

Ulcers should be diagnosed and given a severity grade. Inflammation and/or regenerative hyperplasia, when significant, should be diagnosed along with ulceration as an indicator of the chronicity of the lesion.

references:

Gopinath C, Prentice DE, Lewis DJ. 1987. The urinary system. In: Atlas of Experimental Toxicologic Pathology. Current Histopathology Vol. 13. MTP Press, Norwell, MA, 78.
Abstract: http://onlinelibrary.wiley.com/doi/10.1002/path.1711550414/abstract