Cardiovascular System

Heart, Myocardium - Vacuolation, Cytoplasmic

    Narrative
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a subchronic study. A focal area of cytoplasmic vacuolation of myofibers is present (arrow).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a subchronic study. A focal area of cytoplasmic vacuolation of myofibers is present (arrow).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 1). Large intracytoplasmic vacuoles are present in a group of myofibers (arrows).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 1). Large intracytoplasmic vacuoles are present in a group of myofibers (arrows).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a chronic study. Multiple cardiac myocytes contain cytoplasmic vacuoles (arrows).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a chronic study. Multiple cardiac myocytes contain cytoplasmic vacuoles (arrows).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Some of the cardiac myocytes have variably sized vacuoles (arrows).
    Heart, Myocardium - Vacuolation, Cytoplasmic in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Some of the cardiac myocytes have variably sized vacuoles (arrows).

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC