Respiratory System

Nose - Eosinophilic Material

Narrative

Comment:

Nose - Eosinophilic material is a general term for any amorphous, eosinophilic material that may accumulate in the submucosa in the nasal cavity, including amyloid. A common site for accumulation of eosinophilic material is the ventral nasal septum just dorsal to the vomeronasal organ (Figure 1). This material was previously thought to be amyloid due to its morphologic appearance, but several recent publications by Doi et al. (2007, 2009, 2010) have shown that this material is not, in many cases, amyloid but consists of collagen and complex carbohydrates that may be produced by nasal gland epithelial cells that is Congo red negative. In some cases, however, amyloid deposition is relatively common and can be found in the nasal cavity.

Recommendations:

In the absence of special or immunohistochemical stains showing that the material is amyloid, this change should be diagnosed as "Nose - Eosinophilic material." Since this is a spontaneous change that increases with age and, to date, is not known to be increased with treatment, this lesion should not be diagnosed unless there is clear evidence of a treatment-related effect. This change need not be graded unless grading would clarify a treatment effect.

References:

Doi T, Kokoshima H, Kanno T, Sato J, Wako Y, Tsuchitani M, Matsui T. 2010. New findings concerning eosinophilic substance deposition in mouse nasal septum: Sex difference and no increase in seniles. Toxicol Pathol 38:631-636.

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20448090

Doi T, Kotani Y, Kokoshima H, Kanno T, Wako Y, Tsuchitani M. 2007. Eosinophilic substance is "not amyloid" in the mouse nasal septum. Vet Pathol 44:796-802.

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/18039892

Doi T, Kotani Y, Kokoshima H, Kanno T, Wako Y, Tsuchitani M, Matsui T. 2009. Deposition process of eosinophilic substance in mouse nasal septum. J Vet Med Sci 71:931-935.

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19652481

Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.

All Images

Nose - Eosinophilic material in a male B6C3F1/N mouse from a chronic study. There is bilateral accumulation of an eosinophilic material in the lamina propria of the ventral nasal septum.

Nose - Eosinophilic material in a male B6C3F1/N mouse from a chronic study. The eosinophilic material in the lamina propria separates the glands of the nasal septum.

Authors and Reviewers

Authors

Rodney A. Miller, DVM, PhD, DACVP
NC Pathology Group Manager
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC

Reviewers

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Ronald Herbert, DVM, PhD
NTP Pathologist
Group Leader, Pathology Support Group
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC