Alimentary System

Stomach, Forestomach - Mineralization

Narrative
Comment:
Mineralization of the forestomach usually involves the submucosa, often along the basement membrane (Figure 1), and tunica muscularis (Figure 2). Microscopically, mineralization appears as distinct, crystalline, basophilic material in the tissue. Mineralization in the forestomach usually results from altered calcium-phosphorus metabolism and hyperparathyroidism associated with uremia secondary to end-stage chronic progressive nephropathy.
Recommendations:
Mineralization should be diagnosed and graded based on the extent of the mineralization.
Related Links:
Kidney - Nephropathy, Chronic Progressive
References:

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.

Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.

Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
  • Image of mineralization in the forestomach from a male B6C3F1 mouse in a chronic study

    Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.

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<p>Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.</p>

Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.
<p>Stomach, Forestomach - Mineralization in a male F344/N rat from a chronic study. Mineralization (arrow) of tunica muscularis of forestomach is present.</p>

Stomach, Forestomach - Mineralization in a male F344/N rat from a chronic study. Mineralization (arrow) of tunica muscularis of forestomach is present.

Authors:

Linda H. Kooistra, DVM, PhD, DACVP
Pathologist
Charles River Laboratories, Inc.
Research Triangle Park, NC

Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
Expert in Toxicologic Pathology
Visiting Full Professor of Pathology
Sackler School of Medicine, Tel Aviv University Timrat Israel

Reviewers:

Joel R. Leininger, DVM, PhD
Senior Pathologist
MedImmune
Washington, DC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC