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Stomach, Forestomach - Mineralization

Image of mineralization in the forestomach from a male B6C3F1 mouse in a chronic study
Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.
Figure 1 of 2
Image of mineralization in the forestomach from a male F344/N rat in a chronic study
Stomach, Forestomach - Mineralization in a male F344/N rat from a chronic study. Mineralization (arrow) of tunica muscularis of forestomach is present.
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comment:

Mineralization of the forestomach usually involves the submucosa, often along the basement membrane ( Figure 1image opens in a pop-up window ), and tunica muscularis ( Figure 2image opens in a pop-up window ). Microscopically, mineralization appears as distinct, crystalline, basophilic material in the tissue. Mineralization in the forestomach usually results from altered calcium-phosphorus metabolism and hyperparathyroidism associated with uremia secondary to end-stage chronic progressive nephropathy.

recommendation:

Mineralization should be diagnosed and graded based on the extent of the mineralization.

references:

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.