U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Stomach, Glandular Stomach, Glands - Dilation

Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study. Glandular dilation predominantly at the base of the glands.
Figure 1 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). Multiple glands are affected, and gland profiles are irregular.
Figure 2 of 6
Image of dilation in the glandular stomach glands from a female F344/N rat in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a female F344/N rat from a chronic study. Glandular dilation is present predominantly at the base of the glands.
Figure 3 of 6
Image of dilation in the glandular stomach glands from a female F344/N rat in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a female F344/N rat from a chronic study (higher magnification of Figure 3). Multiple glands are affected.
Figure 4 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study. Glandular dilation is present predominantly at the base of the glands.
Figure 5 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5). Multiple glands are affected.
Figure 6 of 6
next arrow

comment:

Dilated glands usually involve the basal to midportion of the gastric glands, which may become distended with clear fluid, secretion, or cellular debris ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , Figure 4image opens in a pop-up window , Figure 5image opens in a pop-up window , and Figure 6image opens in a pop-up window ). This usually occurs as a focal or multifocal event and may be seen as an aging change in rats. Glandular dilation usually involves multiple glands, and the dilatation is often irregular in profile (i.e., not a well-circumscribed circular structure). Glandular cysts (see Stomach, Glandular stomach, Glands - Cyst) are usually solitary, larger, and lined by attenuated epithelium.

recommendation:

Whenever present, glandular dilation should be diagnosed and graded; grading is based on the number and size of dilated glands and total area of mucosa affected.

references:

Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16.
Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.
Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Frantz JD, Betton GR, Cartwright ME, Crissman JW, Macklin AW, Maronpot RR. 1991. Proliferative lesions of the non-glandular and glandular stomach in rats GI-3. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20.
Full Text: https://www.toxpath.org/docs/SSNDC/StomachProliferativeRat.pdf

National Toxicology Program. 1988. NTP TR-336. Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: https://ntp.niehs.nih.gov/go/8907

National Toxicology Program. 2000. NTP TR-491. Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: https://ntp.niehs.nih.gov/go/10172

National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3’,4,4’-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: https://ntp.niehs.nih.gov/go/33564