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Stomach, Glandular Stomach, Glands - Dilation

Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study. Glandular dilation predominantly at the base of the glands.
Figure 1 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). Multiple glands are affected, and gland profiles are irregular.
Figure 2 of 6
Image of dilation in the glandular stomach glands from a female F344/N rat in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a female F344/N rat from a chronic study. Glandular dilation is present predominantly at the base of the glands.
Figure 3 of 6
Image of dilation in the glandular stomach glands from a female F344/N rat in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a female F344/N rat from a chronic study (higher magnification of Figure 3). Multiple glands are affected.
Figure 4 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study. Glandular dilation is present predominantly at the base of the glands.
Figure 5 of 6
Image of dilation in the glandular stomach glands from a male B6C3F1 mouse in a chronic study
Stomach, Glandular stomach, Glands - Dilation in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5). Multiple glands are affected.
Figure 6 of 6
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comment:

Dilated glands usually involve the basal to midportion of the gastric glands, which may become distended with clear fluid, secretion, or cellular debris ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , Figure 4image opens in a pop-up window , Figure 5image opens in a pop-up window , and Figure 6image opens in a pop-up window ). This usually occurs as a focal or multifocal event and may be seen as an aging change in rats. Glandular dilation usually involves multiple glands, and the dilatation is often irregular in profile (i.e., not a well-circumscribed circular structure). Glandular cysts (see Stomach, Glandular stomach, Glands - Cyst) are usually solitary, larger, and lined by attenuated epithelium.

recommendation:

Whenever present, glandular dilation should be diagnosed and graded; grading is based on the number and size of dilated glands and total area of mucosa affected.

references:

Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16.
Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Frantz JD, Betton GR, Cartwright ME, Crissman JW, Macklin AW, Maronpot RR. 1991. Proliferative lesions of the non-glandular and glandular stomach in rats GI-3. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20.
Full Text: https://www.toxpath.org/docs/SSNDC/StomachProliferativeRat.pdf

National Toxicology Program. 1988. NTP TR-336. Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/8907

National Toxicology Program. 2000. NTP TR-491. Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/10172

National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3’,4,4’-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/33564