Stomach, Glandular Stomach, Glands - Dilation
comment:Dilated glands usually involve the basal to midportion of the gastric glands, which may become distended with clear fluid, secretion, or cellular debris ( Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , and Figure 6 ). This usually occurs as a focal or multifocal event and may be seen as an aging change in rats. Glandular dilation usually involves multiple glands, and the dilatation is often irregular in profile (i.e., not a well-circumscribed circular structure). Glandular cysts (see Stomach, Glandular stomach, Glands - Cyst) are usually solitary, larger, and lined by attenuated epithelium.
recommendation:Whenever present, glandular dilation should be diagnosed and graded; grading is based on the number and size of dilated glands and total area of mucosa affected.
related links:Stomach, Glandular stomach, Glands - Cyst
Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16. Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Frantz JD, Betton GR, Cartwright ME, Crissman JW, Macklin AW, Maronpot RR. 1991. Proliferative lesions of the non-glandular and glandular stomach in rats GI-3. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20. Full Text: https://www.toxpath.org/docs/SSNDC/StomachProliferativeRat.pdf
National Toxicology Program. 1988. NTP TR-336. Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/8907
National Toxicology Program. 2000. NTP TR-491. Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/10172
National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3’,4,4’-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/33564
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