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  • Tooth, Dentin - Basophilic Granules

    Image of baspholic granules in the tooth from a male F344/N rat in a chronic study
    Tooth, Dentin - Basophilic granules in a male F344/N rat from a chronic study. There are numerous, small basophilic granules within the dentin.
    Figure 1 of 2
    Image of baspholic granules in the tooth from a male F344/N rat in a chronic study
    Tooth, Dentin - Basophilic granules in a male F344/N rat from a chronic study. There are numerous, small basophilic granules within the dentin.
    Figure 2 of 2
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    comment:

    Basophilic granules in the dentin ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) are rarely seen in the NTP studies. They are small, round, basophilic globules that occur in a linear pattern within the dentin layer. They have been seen in the predentin and dentin in F344 rats exposed to sodium fluoride for 2 years. Similar deposits are reported to represent calcium fluoride crystal formation that occurs during decalcification of tooth/bone specimens.

    recommendation:

    Basophilic granules should be diagnosed and graded whenever present.

    references:

    Lindemann G, Nylen MU. 1979. Calcium fluoride containing granules produced in vitro in rat bones. Scand J Dent Res 87:381-389.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/295141

    National Toxicology Program. 1996. NTP TR-393. Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC.
    Abstract: http://ntp.niehs.nih.gov/go/12237