Tooth, Dentin - Basophilic Granules
comment:Basophilic granules in the dentin ( Figure 1 and Figure 2 ) are rarely seen in the NTP studies. They are small, round, basophilic globules that occur in a linear pattern within the dentin layer. They have been seen in the predentin and dentin in F344 rats exposed to sodium fluoride for 2 years. Similar deposits are reported to represent calcium fluoride crystal formation that occurs during decalcification of tooth/bone specimens.
recommendation:Basophilic granules should be diagnosed and graded whenever present.
Lindemann G, Nylen MU. 1979. Calcium fluoride containing granules produced in vitro in rat bones. Scand J Dent Res 87:381-389. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/295141
National Toxicology Program. 1996. NTP TR-393. Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/12237
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