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Adrenal Gland - Fibrosis - Gallery

Image of fibrosis in the adrenal gland from a female F344/N rat in a chronic study
Adrenal gland - Fibrosis in a female F344/N rat from a chronic study. A large focal area of mature fibrous connective tissue (F) replaces parts of the normal cortex (C) and medulla (M); there is also focal mineralization (arrow) and a cluster of pigment-laden macrophages (arrowhead).
Image of fibrosis in the adrenal gland from a female F344/N rat in a chronic study
Adrenal gland - Fibrosis in a female F344/N rat from a chronic study (higher magnification of Figure 1). There are scattered fibroblasts and blood vessels within the focus of fibrosis (F); C = cortex, M = medulla.
Image of fibrosis in the adrenal gland capsule from a female F344/N rat in a chronic study
Adrenal gland, Capsule - Fibrosis in a female F344/N rat from a chronic study. Focal fibrosis (arrow) results in thickening, distortion, and undulation of the adrenal capsule.
Image of fibrosis in the adrenal gland capsule from a female F344/N rat in a chronic study
Adrenal gland, Capsule - Fibrosis in a female F344/N rat from a chronic study (higher magnification of Figure 3). Fibrosis of the adrenal capsule (arrow) is characterized by mature collagen sheets interspersed with fibrocytes.
Image of fibrosis in the adrenal gland cortex from a female Sprague-Dawley rat in a chronic study
Adrenal gland, Cortex - Fibrosis in a female Sprague-Dawley rat from a chronic study. Focal fibrosis in the cortex is associated with an organized thrombus (arrow).
Image of fibrosis in the adrenal gland cortex from a female Sprague-Dawley rat in a chronic study
Adrenal gland, Cortex - Fibrosis in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 5). There is residual hemorrhage (arrow) and pigment accumulation (arrowhead) within the focus of fibrosis.
Image of fibrosis in the adrenal gland capsule from a male F344/N rat in a chronic study
Adrenal gland, Capsule - Fibrosis in a male F344/N rat from a subchronic study. There is focal capsular fibrosis (arrow).
Image of fibrosis in the adrenal gland capsule from a male F344/N rat in a chronic study
Adrenal gland, Capsule - Fibrosis in a female F344/N rat from a chronic study. The capsule is thickened by fibrosis (F), most likely a sequela to the necrosis (Ne) in the adjacent retroperitoneal fat. C = cortex, M = medulla.