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Pancreatic Islets - Hypoplasia
Pancreatic islet - hypoplasia. One small hypoplastic islet is present in the pancreas in a female F344/N rat from a chronic study.
Figure 1 of 4
Pancreatic islet - hypoplasia. Higher magnification of the hypoplastic islet shown in Figure 1 in a female F344/N rat from a chronic study.
Figure 2 of 4
Pancreatic islet - hypoplasia. Another hypoplastic islet in the same female F344/N rat from a chronic study as shown in Figures 1 and 2.
Figure 3 of 4
Pancreatic islet - hypoplasia. Islet hypoplasia diagnosed in a treated female F344/N rat from a chronic study: only a single hypoplastic islet (arrow) is present within a large sampling of pancreas.
Figure 4 of 4
comment:
Islet cell hypoplasia is considered a congenital change. In cases of islet cell hypoplasia, typically one or two hypoplastic islets are the only islets present in the section (e.g., only two hypoplastic islets in Figure 1
,
Figure 2
, and
Figure 3
and one hypoplastic islet in
Figure 4
). An adequate section is necessary to confirm this diagnosis since islet size and density vary by region within the pancreas.recommendation:
Hypoplasia of the pancreatic islets should be diagnosed and given a severity grade whenever present.references:
Riley MGI, Boorman GA, Hayashi Y. 1990. Endocrine pancreas. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 545-553. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563