Your browser does not support JavaScript or has JavaScript turned off. The Atlas functions best with JavaScript enabled but may used without JavaScript.

Pancreatic Islets - Hypoplasia

Image of hypoplasia in the pancreatic islet from a female F344/N rat in a chronic study
Pancreatic islet - hypoplasia. One small hypoplastic islet is present in the pancreas in a female F344/N rat from a chronic study.
Figure 1 of 4
Image of hypoplasia in the pancreatic islet from a female F344/N rat in a chronic study
Pancreatic islet - hypoplasia. Higher magnification of the hypoplastic islet shown in Figure 1 in a female F344/N rat from a chronic study.
Figure 2 of 4
Image of hypoplasia in the pancreatic islet from a female F344/N rat in a chronic study
Pancreatic islet - hypoplasia. Another hypoplastic islet in the same female F344/N rat from a chronic study as shown in Figures 1 and 2.
Figure 3 of 4
Image of hypoplasia in the pancreatic islet from a female F344/N rat in a chronic study
Pancreatic islet - hypoplasia. Islet hypoplasia diagnosed in a treated female F344/N rat from a chronic study: only a single hypoplastic islet (arrow) is present within a large sampling of pancreas.
Figure 4 of 4
next arrow

comment:

Islet cell hypoplasia is considered a congenital change. In cases of islet cell hypoplasia, typically one or two hypoplastic islets are the only islets present in the section (e.g., only two hypoplastic islets in Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , and Figure 3image opens in a pop-up window and one hypoplastic islet in Figure 4image opens in a pop-up window ). An adequate section is necessary to confirm this diagnosis since islet size and density vary by region within the pancreas.

recommendation:

Hypoplasia of the pancreatic islets should be diagnosed and given a severity grade whenever present.

references:

Riley MGI, Boorman GA, Hayashi Y. 1990. Endocrine pancreas. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 545-553.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.