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Parathyroid Gland - Fibrosis

Image of fibrosis in the parathyroid gland from a female F344/N rat in a chronic study
Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Extensive fibrosis has replaced the parathyroid parenchyma and extended into the thyroid.
Figure 1 of 2
Image of fibrosis in the parathyroid gland from a female F344/N rat in a chronic study
Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Higher magnification of Figure 1 showing mature collagen surrounding remaining compressed chords of parathyroid parenchymal cells.
Figure 2 of 2
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comment:

Parathyroid fibrosis is characterized by fibrillar, eosinophilic material that expands the interstitium of the parathryorid gland and, when severe, replaces the parenchyma. It is a rarely seen change. There may be extension into the adjacent thyroid parenchyma. The significance of this lesion is uncertain.

recommendation:

Rare lesions such as this should be diagnosed and given a severity grade.

references:

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.