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  • Parathyroid Gland - Fibrosis

    Image of fibrosis in the parathyroid gland from a female F344/N rat in a chronic study
    Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Extensive fibrosis has replaced the parathyroid parenchyma and extended into the thyroid.
    Figure 1 of 2
    Image of fibrosis in the parathyroid gland from a female F344/N rat in a chronic study
    Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Higher magnification of Figure 1 showing mature collagen surrounding remaining compressed chords of parathyroid parenchymal cells.
    Figure 2 of 2
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    comment:

    Parathyroid fibrosis is characterized by fibrillar, eosinophilic material that expands the interstitium of the parathryorid gland and, when severe, replaces the parenchyma. It is a rarely seen change. There may be extension into the adjacent thyroid parenchyma. The significance of this lesion is uncertain.

    recommendation:

    Rare lesions such as this should be diagnosed and given a severity grade.

    references: