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Clitoral Gland - Infiltration Cellular

Image of infiltration cellular in the clitoral gland from a female F344/N rat in a chronic study
Clitoral gland - Infiltration cellular, Lymphocyte and Plasma cells in a female F344/N rat from a chronic study. An infiltration of lymphocytes and plasma cells is present in the stroma.
Figure 1 of 4
Image of infiltration cellular in the clitoral gland from a female F344/N rat in a chronic study
Clitoral gland - Infiltration cellular, Lymphocytes and Plasma cells in a female F344/N rat from a chronic study (higher magnification of Figure 1). A stromal cellular infiltrate of lymphocytes and plasma cells is present.
Figure 2 of 4
Image of infiltration cellular in the clitoral gland from a female F344/N rat in a subchronic study
Clitoral gland - Infiltration cellular, Lymphocyte in a female F344/N from a subchronic study. Lymphocytic infiltration is present.
Figure 3 of 4
Image of infiltration cellular in the clitoral gland from a female F344/N rat in a subchronic study
Clitoral gland - Infiltration cellular, Lymphocyte in a female F344/N from a subchronic study (higher magnification of Figure 3). Lymphocytic infiltration is present in the stroma.
Figure 4 of 4
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comment:

Clitoral gland - Infiltration, cellular may be a spontaneous age-related change in rats and mice but can also be a test-article-related effect. It is characterized by the presence of infiltrating cells (e.g., mononuclear cells, neutrophils, mast cells) within the tissue but with no other evidence of inflammation, such as tissue damage, necrosis, etiologic agents, hemorrhage, congestion, or edema ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window and Figure 4image opens in a pop-up window ). Infiltration cellular must be differentiated from inflammation, in which there is other evidence of inflammation as listed above.

recommendation:

Clitoral gland - Infiltration cellular should be diagnosed and assigned a severity grade. The type of infiltrating cell should be specified as a modifier in the diagnosis.

references:

Copeland-Haines D, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 279-293.

National Toxicology Program. 2011. NTP TR-570. Toxicology and Carcinogenesis Studies of α,β-Thujone (CAS No. 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/36137

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.