Skip to Main Navigation
Skip to Page Content
  • Skip to Atlas Navigation
  • Ovary, Follicle - Polyovular

    Image of normal follicles in the ovary from a female B6C3F1 mouse in a subchronic study
    Ovary - Normal in a female B6C3F1/N mouse from a subchronic study. The two adjacent follicles are distinct; compare with Figure 2.
    Figure 1 of 2
    Image of polyovular follicle in the ovary from a female B6C3F1 mouse in a subchronic study
    Ovary, Follicle - Polyovular in a female B6C3F1/N mouse from a subchronic study. One follicle contains two oocytes, in contrast to the adjacent follicles shown in Figure 1.
    Figure 2 of 2
    next arrow

    comment:

    Individual follicles may be closely adjacent to each other ( Figure 1image opens in a pop-up window ). Each of these follicles contains one oocyte. A polyovular follicle comprises a single follicle containing two oocytes, each with its own nucleus, zona pellucida, and layer of granulosa cells ( Figure 2image opens in a pop-up window ). Polyovular follicles are occasionally seen as a background finding but have been recorded as a treatment-related finding in mice in one subchronic NTP study.

    recommendation:

    Ovary, Follicle - Polyovular should be diagnosed when present, but severity grading is not necessary.

    references:

    Maekawa A, Maita K, Harleman JH. 1996. Changes in the ovary. In: Pathobiology of the Aging Mouse (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 451-467.