Reproductive System, Female
Ovary, Follicle - Polyovular
Narrative
Individual follicles may be closely adjacent to each other (Figure 1). Each of these follicles contains one oocyte. A polyovular follicle comprises a single follicle containing two oocytes, each with its own nucleus, zona pellucida, and layer of granulosa cells (Figure 2). Polyovular follicles are occasionally seen as a background finding but have been recorded as a treatment-related finding in mice in one subchronic NTP study.
Ovary, Follicle - Polyovular should be diagnosed when present, but severity grading is not necessary.
Maekawa A, Maita K, Harleman JH. 1996. Changes in the ovary. In: Pathobiology of the Aging Mouse (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 451-467.
Ovary - Normal in a female B6C3F1/N mouse from a subchronic study. The two adjacent follicles are distinct; compare with Figure 2.
All Images
Ovary - Normal in a female B6C3F1/N mouse from a subchronic study. The two adjacent follicles are distinct; compare with Figure 2.
Ovary, Follicle - Polyovular in a female B6C3F1/N mouse from a subchronic study. One follicle contains two oocytes, in contrast to the adjacent follicles shown in Figure 1.