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Ovary, Follicle - Polyovular

Image of normal follicles in the ovary from a female B6C3F1 mouse in a subchronic study
Ovary - Normal in a female B6C3F1/N mouse from a subchronic study. The two adjacent follicles are distinct; compare with Figure 2.
Figure 1 of 2
Image of polyovular follicle in the ovary from a female B6C3F1 mouse in a subchronic study
Ovary, Follicle - Polyovular in a female B6C3F1/N mouse from a subchronic study. One follicle contains two oocytes, in contrast to the adjacent follicles shown in Figure 1.
Figure 2 of 2
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comment:

Individual follicles may be closely adjacent to each other ( Figure 1image opens in a pop-up window ). Each of these follicles contains one oocyte. A polyovular follicle comprises a single follicle containing two oocytes, each with its own nucleus, zona pellucida, and layer of granulosa cells ( Figure 2image opens in a pop-up window ). Polyovular follicles are occasionally seen as a background finding but have been recorded as a treatment-related finding in mice in one subchronic NTP study.

recommendation:

Ovary, Follicle - Polyovular should be diagnosed when present, but severity grading is not necessary.

references:

Maekawa A, Maita K, Harleman JH. 1996. Changes in the ovary. In: Pathobiology of the Aging Mouse (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 451-467.