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  • Ovary - Metaplasia, Osseous

    Image of metaplasia, osseous in the ovary from a female B6C3F1 mouse in a chronic study
    Ovary - Metaplasia, Osseous in a female B6C3F1/N mouse from a chronic study. An area of osteoid is present in the ovarian parenchyma.
    Figure 1 of 2
    Image of metaplasia, osseous in the ovary from a female B6C3F1 mouse in a chronic study
    Ovary - Metaplasia, Osseous in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). There is an area of osteoid with foci of mineralization.
    Figure 2 of 2
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    comment:

    Ovarian osseous metaplasia ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) is characterized by a well-circumscribed, unencapsulated focus composed of bony trabeculae lined by osteoblasts and osteoclasts; there may also be clumps of amorphous acellular basophilic material, which are most likely mineralized deposits of calcium salts, and mild compression of adjacent ovarian parenchyma. Ovarian metaplasia is a change associated with aging and ovarian atrophy. Osseous metaplasia has been occasionally reported, but the mechanism has not been elucidated.

    recommendation:

    Ovary - Metaplasia, Osseous should be diagnosed and graded whenever present.

    references:

    Greaves P. 2012. Female genital tract. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 4th ed. Elsevier, Amsterdam, 667-724.

    National Toxicology Program. 1997. NTP TR-450. Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.
    Abstract: http://ntp.niehs.nih.gov/go/6044

    Peluso JJ, Gordon LR. 1992. Nonneoplastic and neoplastic changes in the ovary. In: Pathobiology of the Aging Rat (Mohr U, Dungworth DL, Capen CC, eds). ILSI Press, Washington, DC, 351-364.