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Vagina - Angiectasis

Image of angiectasis in the vagina from a female F344/N rat in a chronic study
Vagina - Angiectasis in a female F344/N rat from a chronic study. Dilated blood vessels are present in the wall of the vagina.
Figure 1 of 2
Image of angiectasis in the vagina from a female F344/N rat in a chronic study
Vagina - Angiectasis, in a female F344/N rat from a chronic study (higher magnification of Figure 1). There are dilated, endothelium-lined vessels in the wall of the vagina.
Figure 2 of 2
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comment:

Dilated vessels in the rat vagina are rarely observed. When present as angiectasis, they are usually a collection of prominent dilated blood vessels lined by a single layer of endothelium with flattened nuclei ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). A distinction between angiectasis and hemangioma should be attempted, although the distinction is not always obvious. Hemangiomas tend to be well-circumscribed, unencapsulated masses composed of tightly packed, dilated vascular spaces. Each vascular space is enclosed and lined by a single layer of normal-appearing endothelial cells aligned on collagenous septa, which are usually thin, although some have broad collagenous stroma. In contrast, angiectasis does not usually present a well-circumscribed mass: the dilated vascular channels course irregularly through the tissue.

recommendation:

Vagina - Angiectasis should be diagnosed and graded whenever present.

references:

National Toxicology Program. 1986. NTP TR-250. Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/7108

National Toxicology Program. 1993. NTP TR-431. Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/6006