Lymph Node - Erythrophagocytosis

Lymph node - Erythrophagocytosis in a female F344/N rat from a chronic study. Numerous macrophages with intracytoplasmic erythrocytes (arrows) and extravasated erythrocytes fill the medullary sinus of this lymph node.
Figure 1 of 2
comment:
Erythrophagocytosis in lymph nodes consists of macrophages within sinuses that phagocytize extravasated, old, and/or damaged erythrocytes ( Figure 1

recommendation:
When erythrophagocytosis is present within lymph nodes, it should be diagnosed and graded.references:
Frith CH, Ward JM, Chandra M, Losco PE. 2000. Non-proliferative lesions of the hematopoietic system in rats. In: Guides for Toxicologic Pathology.TP/ARP/AFIP, Washington, DC. Full Text: https://www.toxpath.org/docs/SSNDC/HematopoieticNonprolifRat.pdf
National Toxicology Program. 2011. NTP TR-561. Toxicology and Carcinogenesis Studies of Tetralin (CAS No. 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/33575
Web page last updated on: January 27, 2015