U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Lymph Node - Erythrophagocytosis

Image of erythrophagocytosis in the lymph node from a female F344/N rat in a chronic study
Lymph node - Erythrophagocytosis in a female F344/N rat from a chronic study. Numerous macrophages with intracytoplasmic erythrocytes (arrows) and extravasated erythrocytes fill the medullary sinus of this lymph node.
Figure 1 of 2
Image of erythrophagocytosis in the lymph node from a female F344/N rat in a chronic study
Lymph node - Erythrophagocytosis in a female F344/N rat from a chronic study (higher magnification of Figure 1). Macrophages within the medullary sinus contain variable numbers of erythrocytes and/or pigment within their cytoplasm (arrows).
Figure 2 of 2
next arrow
View all images

comment:

Erythrophagocytosis in lymph nodes consists of macrophages within sinuses that phagocytize extravasated, old, and/or damaged erythrocytes ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window , arrows). Erythrophagocytosis does not occur under normal conditions and is most often associated with lymph node hemorrhage, congestion, sinus erythrocytosis, and autoimmune and other immunopathologic conditions.

recommendation:

When erythrophagocytosis is present within lymph nodes, it should be diagnosed and graded.

references:

Frith CH, Ward JM, Chandra M, Losco PE. 2000. Non-proliferative lesions of the hematopoietic system in rats. In: Guides for Toxicologic Pathology.TP/ARP/AFIP, Washington, DC.
Full Text: https://www.toxpath.org/docs/SSNDC/HematopoieticNonprolifRat.pdf

National Toxicology Program. 2011. NTP TR-561. Toxicology and Carcinogenesis Studies of Tetralin (CAS No. 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.
Abstract: https://ntp.niehs.nih.gov/go/33575

Back to top

Web page last updated on: January 27, 2015