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Spleen - Erythrophagocytosis

Image of erythrophagocytosis in the spleen from a male B6C3F1/N mouse in a chronic study
Spleen - Erythrophagocytosis in a male B6C3F1/N mouse from a chronic study. Numerous macrophages (arrows) within the splenic red pulp contain intracytoplasmic erythrocytes.
Figure 1 of 2
Image of erythrophagocytosis in the spleen from a male B6C3F1/N mouse in a chronic study
Spleen - Erythrophagocytosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Macrophages contain intracytoplasmic erythrocytes and eosinophilic cellular debris (arrows).
Figure 2 of 2
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comment:

Erythrophagocytosis in the spleen consists of macrophages (mainly in the splenic red pulp) that phagocytize extravasated, old, and/or damaged erythrocytes ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window , arrows). Splenic erythrophagocytosis can be increased in such conditions as chronic congestion or hemorrhage, treatment-related hemolytic anemia, or methemoglobinemia or secondary to the presence of malignant neoplasms.

recommendation:

Diagnose and grade erythrophagocytosis in the spleen if it is considered to be treatment related.

references:

National Toxicology Program. 2000. NTP TR-491. Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/10172

Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.

Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.