Spleen - Hyperplasia, Plasma Cell


comment:
Plasma cell hyperplasia is a common, often mild, lesion in the spleen of rodents, particularly mice. It consists of plasma cells and/or plasmablasts that migrate to the red pulp from the white pulp (lymphoid follicles, germinal centers) following acute or chronic antigen-specific stimulation ( Figure 1

recommendation:
Plasma cell hyperplasia should be diagnosed when the number of plasma cells exceeds that seen in concurrent controls. When diagnosed, it should be graded.references:
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