Immune System

Spleen - Pigment

    Narrative
    Spleen - Pigment in a male F344/N rat from a chronic study. Multifocal macrophages with intracytoplasmic dark-brown granular pigment (arrow) are present within the splenic red pulp.
    Spleen - Pigment in a female Sprague-Dawley rat from a chronic study. Macrophages with intracytoplasmic golden-brown pigment (arrow) are focally present within the splenic white pulp.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC