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Penis - Fibrosis
Penis - Fibrosis. The large space (asterisk) is an artifact. The urethra is markedly dilated (arrow) in a male B6C3F1 mouse from a chronic study.
Figure 1 of 2
Penis - Fibrosis. Higher magnification of Figure 1 showing the dilated urethra (asterisk) lined by flattened epithelium and pieces of stratified squamous epithelium trapped in the fibrotic reaction (arrows) in a male B6C3F1 mouse from a chronic study.
Figure 2 of 2
comment:
Fibrosis of the penis is characterized by abundant fibroblasts with collagen deposition that expands the tissue surrounding the penile urethra ( Figure 1
and
Figure 2
). Penile fibrosis is uncommon, and causal association with chemical agents has not been established.