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Penis - Fibrosis

Image of fibrosis in the penis from a male B6C3F1 mouse in a chronic study
Penis - Fibrosis. The large space (asterisk) is an artifact. The urethra is markedly dilated (arrow) in a male B6C3F1 mouse from a chronic study.
Figure 1 of 2
Image of fibrosis in the penis from a male B6C3F1 mouse in a chronic study
Penis - Fibrosis. Higher magnification of Figure 1 showing the dilated urethra (asterisk) lined by flattened epithelium and pieces of stratified squamous epithelium trapped in the fibrotic reaction (arrows) in a male B6C3F1 mouse from a chronic study.
Figure 2 of 2
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comment:

Fibrosis of the penis is characterized by abundant fibroblasts with collagen deposition that expands the tissue surrounding the penile urethra ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Penile fibrosis is uncommon, and causal association with chemical agents has not been established.

recommendation:

This lesion should be diagnosed and given a severity grade.

references:

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.