Reproductive System, Male

Penis - Fibrosis

Narrative
Comment:
Fibrosis of the penis is characterized by abundant fibroblasts with collagen deposition that expands the tissue surrounding the penile urethra (Figure 1 and Figure 2). Penile fibrosis is uncommon, and causal association with chemical agents has not been established.
Recommendations:
This lesion should be diagnosed and given a severity grade.
References:

References not listed.

  • Image of fibrosis in the penis from a male B6C3F1 mouse in a chronic study

    Penis - Fibrosis. The large space (asterisk) is an artifact. The urethra is markedly dilated (arrow) in a male B6C3F1 mouse from a chronic study.

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<p>Penis - Fibrosis. The large space (asterisk) is an artifact. The urethra is markedly dilated (arrow) in a male B6C3F1 mouse from a chronic study.</p>

Penis - Fibrosis. The large space (asterisk) is an artifact. The urethra is markedly dilated (arrow) in a male B6C3F1 mouse from a chronic study.
<p>Penis - Fibrosis. Higher magnification of Figure 1 showing the dilated urethra (asterisk) lined by flattened epithelium and pieces of stratified squamous epithelium trapped in the fibrotic reaction (arrows) in a male B6C3F1 mouse from a chronic study.</p>

Penis - Fibrosis. Higher magnification of Figure 1 showing the dilated urethra (asterisk) lined by flattened epithelium and pieces of stratified squamous epithelium trapped in the fibrotic reaction (arrows) in a male B6C3F1 mouse from a chronic study.

Authors

Dianne M. Creasy, PhD, Dip RCPath, FRCPath
Dianne Creasy Consulting LLC
Pipersville, PA

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Dipak K. Giri, DVM, PHD, DACVP
Toxicologic Pathologist
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC

Reviewers

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC