Reproductive System, Male
Prostate, Acinus - Atrophy
Narrative
). Figure 1 and Figure 2 represent the dorsolateral lobe of normal prostate for comparison. In general, atrophy involves all lobes of the prostate. Inhibition of gonadal steroid and pituitary hormones results in atrophy of testes and accessory sex organs, including prostate. Inhibitors of 5α-reductases, enzymes involved in intraprostatic conversion of testosterone to its biologically active form dihydrotestosterone, such as finasteride and epristeride, are known to induce atrophy of prostate. Similarly, antiandrogenic substances such as hydroxyflutamide cause prostatic atrophy.Estrogens decrease the volume of the glandular epithelium and increase the fibromuscular stroma in both ventral prostate and seminal vesicle. Deficiency of the Egr family of zinc finger transcription factors such as Egr4 and Egr1, as in Egr4-Egr1 double-mutant mice, leads to atrophy of prostate, testis, epididymis, and seminal vesicle. Spontaneous prostatic atrophy is an age-related lesion.
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Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098692/Gayton F, Bellido C. Aguilar R, Lucena MC. 1986. Morphometric analysis of the rat ventral prostate and seminal vesicles during prepubertal development: Effects of neonatal treatment with estrogen. Biol Reprod 35:219-225.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/3741952Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441.
Abstract: http://catalog.hathitrust.org/Record/008994685Greaves P. 2007. Male genital tract. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation. 3rd ed. Academic Press, San Diego, 661-716.
Abstract: http://www.sciencedirect.com/science/book/9780444527714Quin LH, Wang XL, Tu ZH. 2001. Atrophy and apoptosis in ventral prostate of rats induced by 5 alpha-reductase inhibitor epristeride. Acta Pharmacol Sin 22:399-404.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11743885Rittmaster RS, Manning AP, Wright AS, Thomas LN, Whitefield S, Norman RW, Lazier CB, Rowden G. 1995. Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5alpha-reductase inhibitor finasteride. Endocrinology 136:741-748.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7835306
Prostate - Normal. Normal dorsolateral prostate for comparison with Figure 3 in a male F344/N rat from a subchronic study.
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