Testis, Seminiferous Tubule - Necrosis

Testis, Seminiferous tubule - Necrosis in a male Swiss Webster mouse from a chronic study. Vacuoles are present in affected seminiferous tubules.
Figure 1 of 4

Testis, Seminiferous tubule - Necrosis in a male Swiss Webster mouse from a chronic study. This higher magnification of Figure 1 shows that both germ cells and Sertoli cells are undergoing necrosis.
Figure 2 of 4

Testis, Seminiferous tubule - Necrosis in a male B6C3F1 mouse from a chronic study. There is complete effacement of the testis associated with infarction.
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comment:
Seminiferous tubule necrosis ( Figure 1





Chemically induced testicular necrosis has been described in rodents administered cadmium, which is an endothelial toxicant in the testis of rodents. Necrosis can also be caused by agents causing vascular thrombosis in the testis. A characteristically focal necrosis at the frontal lower part of the rat testis ( Figure 4

recommendation:
Seminiferous tubule necrosis should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appear to be related to chemical administration. If both testes are affected, the diagnosis should be qualified as bilateral and given a severity grade based on the more severely affected testis. If vascular thrombi are evident as a precipitating cause, that fact should be mentioned in the pathology narrative. Associated lesions, such as inflammation, should be diagnosed separately if warranted by severity.references:
Aoki A, Hoffer AP. 1978. Reexamination of the lesions in rat testis caused by cadmium. Biol Reprod 18:579-591. Abstract: https://doi.org/10.1095/biolreprod18.4.579
Creasy DM. 2001. Pathogenesis of male reproductive toxicity. Toxicol Pathol 29:64-76. Full Text: http://tpx.sagepub.com/content/29/1/64.full.pdf
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: https://doi.org/10.1177/0192623312454337
Web page last updated on: August 19, 2014