Figure 1. Normal skeletal muscle in a male B6C3F1/N mouse from a subchronic study. Represented is a longitudinal section from a thigh muscle.
Figure 2. Normal skeletal muscle in a male B6C3F1/N mouse from a subchronic study. Represented is a cross section from a lumbar muscle.
Segmental muscle fiber degeneration accompanied by regeneration is a relatively common histologic finding in which the presence, and the relative proportions, of the two processes is contingent upon the temporal sequence following insult. Frank necrosis, though unusual, may be seen following intramuscular injection or interruption of vascular perfusion (ischemia).
Web page last updated on: March 11, 2015