U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Skeletal Muscle

Image of normal in the skeletal muscle from a male B6C3F1/N mouse in a subchronic study

Figure 1. Normal skeletal muscle in a male B6C3F1/N mouse from a subchronic study. Represented is a longitudinal section from a thigh muscle.

Normal skeletal muscle fibers ( Figure 1 and Figure 2 ) are multinucleated cells and the nuclei are located peripherally within the cell. Viable myofibers have characteristic cross striations, which are visible only in longitudinal sections. Responses of skeletal muscle to insult and stimulation represent a robust constellation of mixed reactions. Stimulation can lead to hypertrophy, while disuse can result in atrophy; both are generally readily reversible.
Image of normal in the skeletal muscle from a male B6C3F1/N mouse in a subchronic study

Figure 2. Normal skeletal muscle in a male B6C3F1/N mouse from a subchronic study. Represented is a cross section from a lumbar muscle.


Segmental muscle fiber degeneration accompanied by regeneration is a relatively common histologic finding in which the presence, and the relative proportions, of the two processes is contingent upon the temporal sequence following insult. Frank necrosis, though unusual, may be seen following intramuscular injection or interruption of vascular perfusion (ischemia).

Back to top

Web page last updated on: March 11, 2015