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National Toxicology Program
National Toxicology Program - U.S. Department of Health and Human Services

Nonneoplastic Lesion Atlas

A guide for standardizing terminology in toxicologic pathology for rodents 

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  3. Nonneoplastic Lesion Atlas - National Toxicology Program
  4. Nervous System
  • Atlas Home
  • Alimentary System
    • Esophagus
      • Amyloid
      • Angiectasis
      • Dilation
      • Diverticulum
      • Edema
      • Hemorrhage
      • Hyperkeratosis
      • Hyperplasia
      • Inflammation
      • Muscularis - Degeneration
      • Ulcer
    • Oral Mucosa
      • Cyst, Squamous
      • Foreign Body
      • Gingiva - Ectopic Tissue
      • Hyperplasia, Cystic, Keratinizing
      • Hyperplasia, Squamous
      • Inflammation
      • Necrosis
      • Ulcer
    • Salivary Gland
      • Amyloid
      • Atrophy
      • Duct - Concretion
      • Duct - Cyst
      • Duct - Dilation
      • Duct - Metaplasia, Squamous
      • Edema
      • Fibrosis
      • Hemorrhage
      • Hyperplasia
      • Infiltration, Cellular
      • Inflammation
      • Karyomegaly
      • Necrosis
      • Parotid - Basophilic Hypertrophic Focus
      • Parotid, Acinus - Hypertrophy
      • Submandibular - Secretory Depletion
      • Submandibular, Duct - Cytoplasmic Alteration
      • Vacuolation, Cytoplasmic
    • Stomach, Forestomach
      • Angiectasis
      • Cyst
      • Diverticulum
      • Ectopic Tissue
      • Edema
      • Epithelium - Degeneration
      • Epithelium - Hyperplasia, Atypical
      • Epithelium - Hyperplasia, [Focal, Diffuse]
      • Erosion
      • Fibrosis
      • Foreign Body
      • Hemorrhage
      • Hyperkeratosis
      • Inflammation
      • Mineralization
      • Necrosis
      • Parasite, Metazoan
      • Perforation
      • Ulcer
    • Stomach, Glandular Stomach
      • Amyloid
      • Angiectasis
      • Atrophy
      • Ectopic Tissue
      • Edema
      • Epithelium - Hyperplasia
      • Epithelium - Hyperplasia, Atypical
      • Epithelium - Vacuolation, Cytoplasmic
      • Erosion
      • Fibrosis
      • Foreign body
      • Glands - Cyst
      • Glands - Dilation
      • Hemorrhage
      • Hyaline Droplet
      • Infiltration, Cellular
      • Inflammation
      • Metaplasia, Intestinal
      • Metaplasia, Squamous
      • Mineralization
      • Necrosis
      • Neuroendocrine Cell - Hyperplasia
      • Pigment
      • Thrombus
      • Ulcer
    • Tongue
      • Angiectasis
      • Edema
      • Epithelium - Degeneration
      • Epithelium - Hyperplasia
      • Fibrosis
      • Glands - Cyst
      • Hemorrhage
      • Hyperkeratosis
      • Inflammation
      • Mucosa - Fibroepithelial Polyp
      • Necrosis
      • Squamous Cyst
      • Ulcer
    • Tooth
      • Ameloblast - Atrophy
      • Ameloblast - Metaplasia, Squamous
      • Angiectasis
      • Dental Dysplasia
      • Denticle
      • Dentin - Basophilic Granules
      • Fibrosis
      • Incisor - Degeneration
      • Inflammation
      • Necrosis
      • Odontoblast - Degeneration
      • Odontoblast - Necrosis
      • Periodontal Pocket
      • Pulp - Osteodentin
      • Pulp - Thrombus
  • Cardiovascular System
    • Blood Vessel
      • Amyloid
      • Arteriosclerosis
      • Artery - Hypertrophy, Medial
      • Embolus
      • Metaplasia
      • Mineral
      • Necrosis
      • Pigment
      • Polyarteritis Nodosa
      • Proliferation, Intimal
      • Thrombus
    • Heart
      • Amyloid
      • Atrophy
      • Cardiomyopathy
      • Cyst
      • Hemorrhage
      • Inflammation
      • Mineral
      • Myocardium - Necrosis
      • Myocardium - Vacuolation, Cytoplasmic
      • Thrombus
      • Valve - Degeneration, Myxomatous
  • Endocrine System
    • Adrenal Gland
      • Accessory Adrenocortical Nodule
      • Amyloid
      • Angiectasis
      • Cortex - Atrophy
      • Cortex - Cellular Atypia
      • Cortex - Degeneration, Cystic
      • Cortex - Hyperplasia, Subcapsular
      • Cortex - Hypertrophy
      • Cortex - Vacuolization, Cytoplasmic
      • Cortex, X-Zone - Atrophy
      • Cyst
      • Extramedullary Hematopoiesis
      • Fibrosis
      • Hemorrhage
      • Hyperplasia
      • Infarct
      • Inflammation
      • Mineralization
      • Necrosis
      • Pigment
    • Pancreatic Islets
      • Angiectasis
      • Cyst
      • Hyperplasia
      • Hypoplasia
      • Metaplasia, Hepatocyte
      • Necrosis
    • Parathyroid Gland
      • Angiectasis
      • Cyst, Congenital
      • Ectopic Tissue
      • Fibrosis
      • Hyperplasia, Diffuse
      • Hyperplasia, Focal
      • Syncytial Giant Cell
    • Pituitary Gland
      • Cyst
      • Hyperplasia
      • Pars Distalis - Atrophy
      • Pars Distalis - Necrosis
      • Rathke's Cleft - Dilation
    • Thyroid Gland
      • C Cell Hyperplasia
      • Cyst, Congenital
      • Ectopic Tissue
      • Follicle - Degeneration
      • Follicle - Dilation
      • Follicle - Mineralization
      • Follicle - Pigment
      • Follicle, Epithelium - Hyperplasia
      • Follicular Cell - Hypertrophy
      • Inflammation
  • Hematopoietic System
    • Bone Marrow
      • Angiectasis
      • Fibrosis
      • Gelatinous Transformation
      • Hypercellularity
      • Hypocellularity
      • Infiltration Cellular, Histiocyte
      • Infiltration Cellular, Mast Cell
      • Inflammation
      • Necrosis
      • Pigment
  • Hepatobiliary System
    • Gallbladder
      • Epithelium - Hyperplasia
      • Hyaline Droplet Accumulation
      • Inflammation
    • Liver
      • Amyloid
      • Angiectasis
      • Atrophy
      • Bile Duct - Cyst
      • Bile Duct - Hyperplasia
      • Cholangiofibrosis
      • Extramedullary Hematopoiesis
      • Fatty Change
      • Focus
      • Hepatocyte - Apoptosis
      • Hepatocyte - Cytoplasmic Inclusions
      • Hepatocyte - Glycogen Accumulation
      • Hepatocyte – Hyperplasia, Nodular
      • Hepatocyte - Hypertrophy
      • Hepatocyte – Increased Mitosis
      • Hepatocyte - Karyomegaly
      • Hepatodiaphragmatic Nodule
      • Inflammation
      • Intrahepatocellular Erythrocytes
      • Kupffer Cell - Hyperplasia
      • Necrosis
      • Oval Cell - Hyperplasia
      • Pigment
      • Stellate Cell - Hyperplasia
      • Tension Lipidosis
  • Immune System
    • Lymph Node
      • Angiectasis
      • Apoptosis, Lymphocyte
      • Atrophy
      • Congestion
      • Erythrophagocytosis
      • Extramedullary Hematopoiesis
      • Hyperplasia, Lymphocyte
      • Hyperplasia, Mast Cell
      • Hyperplasia, Plasma Cell
      • Inflammation
      • Inflitration, Cellular, Histiocyte
      • Lymphatic Sinus, Ectasia
      • Necrosis
      • Pigment
      • Sinus Erythrocytosis
    • Spleen
      • Accessory Spleen
      • Adipocyte Metaplasia
      • Amyloid
      • Angiectasis
      • Apoptosis, Lymphocyte
      • Atrophy
      • Congestion
      • Erythrophagocytosis
      • Extramedullary Hematopoiesis
      • Fibrosis
      • Hemorrhage
      • Hyperplasia, Lymphocyte
      • Hyperplasia, Mast Cell
      • Hyperplasia, Plasma Cell
      • Inflammation
      • Necrosis
      • Pigment
      • Red Pulp - Hyperplasia, Stromal
    • Thymus
      • Amyloid
      • Apoptosis, Lymphocyte
      • Atrophy
      • Atypical Hyperplasia, Lymphocyte
      • Cyst
      • Ectopic Tissue
      • Hemorrhage
      • Hyperplasia, Epithelial
      • Inflammation
      • Involution
      • Mineralization
      • Necrosis, Lymphocyte
      • Pigment
  • Integumentary System
    • Skin
      • Amyloid
      • Atrophy
      • Ectoparasites
      • Fibroadnexal Hamartoma
      • Fibrosis
      • Hair Follicle - Dilatation and Cyst
      • Hemorrhage
      • Hyperkeratosis
      • Hyperplasia
      • Inflammation
      • Necrosis
      • Pigment
      • Pustule
      • Ulcer and Erosion
      • Vesicle
  • Musculoskeletal System
    • Bone
      • Callus
      • Cyst
      • Decreased Bone
      • Fibro-osseous Lesion
      • Fibrous Osteodystrophy
      • Fracture
      • Increased Bone
      • Increased Osteoid
      • Inflammation
      • Intervertebral Disc - Degeneration
      • Joint - Degeneration
      • Joint - Inflammation
      • Necrosis
      • Osteochondrosis
      • Physeal Dysplasia
    • Skeletal Muscle
      • Angiectasis
      • Atrophy
      • Cyst
      • Degeneration
      • Edema
      • Fibrosis
      • Hemorrhage
      • Hypertrophy
      • Inflammation
      • Mineralization
      • Necrosis
      • Regeneration
  • Nervous System
    • Brain
      • Angiectasis
      • Axonopathy
      • Cholesterol Clefts
      • Dysplasia
      • Epidermoid Cyst
      • Hemorrhage
      • Hydrocephalus
      • Inflammation
      • Intramyelinic Edema
      • Leptomeninges - Hamartoma, Lipomatous
      • Microgliosis
      • Mineralization
      • Necrosis
      • Neuron - Cell Loss
      • Neuron - Chromatolysis
      • Neuron - Degeneration
      • Neuron - Necrosis
      • Pigment
    • Nerve
      • Ectopic Neuron
    • Spinal Cord
      • Demyelination
      • Dorsal Root Ganglion, Neuron - Vacuolation
  • Reproductive System, Female
    • Clitoral Gland
      • Angiectasis
      • Atrophy
      • Duct - Dilation
      • Fibrosis
      • Hyperplasia
      • Infiltration Cellular
      • Inflammation
      • Mineralization
      • Pigment
    • Ovary
      • Amyloid
      • Angiectasis
      • Atrophy
      • Bursa - Cyst
      • Corpus Luteum - Cyst
      • Cyst
      • Cyst, Epithelial
      • Epithelium - Hyperplasia
      • Fatty Change
      • Follicle - Cyst
      • Follicle - Polyovular
      • Hyperplasia, Sertoliform
      • Infiltration Cellular
      • Inflammation
      • Interstitial Cell - Hyperplasia
      • Mesonephric Duct Remnant
      • Metaplasia, Osseous
      • Mineral
      • Necrosis
      • Paraovarian Tissue - Cyst
      • Pigment
      • Thrombosis
    • Oviduct
      • Atrophy
      • Inflammation
      • Mesonephric Duct Remnant
      • Necrosis
    • Uterus
      • Adenomyosis
      • Amyloid
      • Atrophy
      • Cervix - Cyst, Squamous
      • Decidual Reaction
      • Dilation
      • Edema
      • Endometrium - Hyperplasia, Cystic
      • Endometrium - Metaplasia, Squamous
      • Fibrosis
      • Hemorrhage
      • Hyperplasia, Atypical
      • Hyperplasia, Stromal
      • Inflammation
      • Mesonephric Duct Remnant
      • Necrosis
      • Pigment
      • Thrombus
    • Vagina
      • Angiectasis
      • Cyst
      • Dilation
      • Epithelium - Hyperplasia
      • Fibrosis
      • Hypertrophy, Stromal
      • Inflammation
      • Mucification
      • Necrosis
      • Pigment
      • Ulcer
  • Reproductive System, Male
    • Coagulating Gland
      • Atrophy
      • Dilation, Acinar
      • Hyperplasia
      • Inflammation
    • Ductus Deferens
      • Inflammation
      • Mineralization
    • Epididymis
      • Amyloid
      • Duct - Atrophy
      • Duct - Dilation
      • Duct - Exfoliated Germ Cell
      • Epithelium - Apoptosis
      • Epithelium - Degeneration
      • Epithelium - Karyomegaly
      • Epithelium - Vacuolation
      • Hypospermia
      • Inflammation
      • Sperm Granuloma
      • Sperm Stasis
      • Spermatocele
    • Penis
      • Epithelium - Hyperplasia
      • Fibrosis
      • Inflammation
      • Prepuce - Inflammation
    • Preputial Gland
      • Atrophy
      • Duct - Dilation
      • Hyperplasia
      • Inflammation
      • Metaplasia, Osseous
      • Mineralization
      • Necrosis
    • Prostate
      • Acinus - Atrophy
      • Acinus - Cyst(s), Mucinous
      • Acinus - Dilation
      • Acinus - Secretory alteration (concretions)
      • Edema
      • Epithelium - Degeneration
      • Epithelium - Hyperplasia
      • Inflammation
      • Mineralization
    • Seminal Vesicle
      • Amyloid
      • Atrophy
      • Dilation
      • Epithelium - Hyperplasia
      • Inflammation
      • Mineralization
    • Testis
      • Amyloid
      • Atypical Residual Bodies
      • Fibrosis
      • Germ Cell - Exfoliation
      • Germinal Epithelium - Atrophy
      • Germinal Epithelium - Degeneration
      • Inflammation
      • Interstitial Cell - Hyperplasia
      • Interstitial Cell - Syncytial Cells
      • Interstitial Cell - Vacuolation
      • Mineralization
      • Pigment
      • Rete Dilation
      • Rete Hyperplasia
      • Seminiferous Tubule - Dilation
      • Seminiferous Tubule - Giant Cells
      • Seminiferous Tubule - Necrosis
      • Seminiferous Tubule - Retention, Spermatid
      • Seminiferous Tubule - Vacuolation
      • Sperm Granuloma
      • Sperm Stasis
      • Spermatocele
  • Respiratory System
    • Lung
      • Alveolar/Bronchiolar Epithelium - Hyperplasia
      • Amyloid
      • Atypia, Cellular
      • Bronchiectasis
      • Crystals
      • Emphysema
      • Epithelium - Degeneration
      • Epithelium - Necrosis
      • Epithelium, Alveolus - Hyperplasia
      • Fibrosis
      • Foreign Body
      • Foreign Material
      • Glands - Cyst
      • Hemorrhage
      • Hypertrophy, Smooth Muscle
      • Infiltration Cellular, Histiocyte
      • Inflammation
      • Keratinizing Cyst
      • Metaplasia, Goblet Cell
      • Metaplasia, Osseous
      • Metaplasia, Squamous
      • Mineral
      • Pigment
      • Proteinosis
      • Regeneration
      • Ulceration
      • Vacuolization, Cytoplasmic
    • Nose
      • Bone - Periosteal Proliferation
      • Concretion
      • Eosinophilic Material
      • Epithelium - Accumulation, Hyaline Droplet
      • Epithelium - Degeneration
      • Epithelium - Fibrosis
      • Epithelium - Hyperplasia
      • Epithelium - Hyperplasia, Atypical
      • Epithelium - Metaplasia, Squamous
      • Epithelium - Necrosis
      • Epithelium - Regeneration
      • Foreign Body
      • Foreign Material
      • Fungus
      • Hyperplasia, Goblet Cell
      • Inflammation
      • Nerve - Atrophy
      • Olfactory Epithelium - Atrophy
      • Olfactory Epithelium - Hyperplasia, Basal Cell
      • Olfactory Epithelium - Metaplasia, Respiratory
      • Olfactory Epithelium, Glands - Hyperplasia
      • Olfactory Epithelium, Glands - Metaplasia
      • Pigment
      • Polyp, Inflammatory
      • Respiratory Epithelium, Glands - Dilation
      • Septum - Perforation
      • Steno's Glands - Degeneration
      • Turbinate - Atrophy
      • Turbinate - Hyperostosis
      • Turbinate - Synechia
  • Special Senses System
    • Ear
      • Canal - Dilation
      • Epithelium - Hyperplasia
      • Inflammation
      • Proteinaceous Fluid
      • Ulcer
    • Eye
      • Anterior Chamber - Hemorrhage
      • Anterior Chamber - Proteinaceous Fluid
      • Conjunctiva - Edema
      • Cornea - Cyst
      • Cornea - Edema
      • Cornea - Fibrosis
      • Cornea - Hyperplasia, Squamous
      • Cornea - Metaplasia, Goblet Cell
      • Cornea - Mineralization
      • Cornea - Necrosis
      • Cornea - Neovascularization
      • Cornea - Ulcer
      • Cornea - Vacuolation, Cytoplasmic
      • Inflammation
      • Iris - Synechia
      • Lens - Cataract
      • Optic Nerve - Degeneration
      • Optic Nerve - Gliosis
      • Phthisis Bulbi
      • Retina - Degeneration
      • Retina - Detachment
      • Retina - Dysplasia
      • Retina - Gliosis
      • Retina - Hemorrhage
      • Retrobulbar - Hemorrhage
      • Sclera - Metaplasia, Osseous
      • Vitreous - Fibrosis
      • Vitreous - Hemorrhage
      • Vitreous - Proteinaceous Fluid
    • Harderian Gland
      • Atrophy
      • Cyst
      • Dilation
      • Hemorrhage
      • Hyperplasia
      • Infiltration Cellular, Mononuclear Cell
      • Inflammation
      • Necrosis
      • Pigment
    • Lacrimal Gland
      • Atrophy
      • Infiltration Cellular, Mononuclear Cell
      • Inflammation
      • Karyomegaly
      • Metaplasia, Harderian
    • Zymbal's Gland
      • Duct - Cyst
      • Hyperplasia
      • Hypertrophy
      • Inflammation
  • Urinary System
    • Kidney
      • Amyloid
      • Calculus
      • Crystals
      • Cyst
      • Ectopic Tissue
      • Fibrosis
      • Glomerulonephritis
      • Glomerulosclerosis
      • Glomerulus - Metaplasia
      • Hyaline Glomerulopathy
      • Infarct
      • Inflammation
      • Interstitium - Infiltration, Cellular
      • Karyomegaly
      • Metaplasia, Osseous
      • Mineralization
      • Nephroblastematosis
      • Nephropathy, Chronic Progressive
      • Nephropathy, Obstructive
      • Papilla - Necrosis
      • Papilla, Epithelium - Hyperplasia
      • Pelvis - Dilation
      • Renal Tubule - Accumulation, Hyaline Droplet
      • Renal Tubule - Atypical Tubule Hyperplasia
      • Renal Tubule - Cast
      • Renal Tubule - Cytoplasmic Alteration
      • Renal Tubule - Degeneration
      • Renal Tubule - Dilation
      • Renal Tubule - Hyperplasia, Amphophilic-Vacuolar
      • Renal Tubule - Hyperplasia, Oncocytic
      • Renal Tubule - Hypertrophy
      • Renal Tubule - Necrosis
      • Renal Tubule - Regeneration
      • Renal Tubule - Vacuolation, Cytoplasmic
      • Urothelium - Hyperplasia
    • Ureter
      • Dilation
    • Urinary Bladder
      • Angiectasis
      • Calculus/Crystal
      • Dilation
      • Edema
      • Hemorrhage
      • Infiltration Cellular, Lymphocyte
      • Inflammation
      • Metaplasia
      • Mineralization
      • Necrosis
      • Pigment
      • Proteinaceous Plug
      • Ulcer
      • Urothelium - Cytoplasmic Granules
      • Urothelium - Hyperplasia
      • Vacuolation, Cytoplasmic

Nervous System

Brain
Brain
Nerve
Nerve
Spinal cord
Spinal Cord
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Web page last updated onLast updated August 3, 2021
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