Respiratory System

Lung, Epithelium - Necrosis

    Narrative
    Lung, Bronchiole, Epithelium, Bronchiole - Necrosis in a female B6C3F1/N mouse from a subchronic study. The epithelial cells are fragmented, with pyknotic and karyorrhectic nuclei.
    Lung, Epithelium - Necrosis in a male Wistar Han rat from a chronic study. There is a large area of coagulative necrosis surrounded by suppurative inflammation.
    Lung, Epithelium, Alveolus - Necrosis in a female F344/N rat from a subchronic study. There is loss of epithelial cells, and many of the interstitial cells have pyknotic nuclei.
    Lung, Epithelium, Alveolus - Necrosis in a female F344/N rat from a subchronic study. In this focal lesion, there is loss of epithelial and interstitial cells.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC