Respiratory System

Lung - Foreign Body

    Narrative
    Lung, Bronchus - Foreign body in a male Harlan Sprague-Dawley rat from a chronic study. Multiple foreign bodies are present in a bronchus.
    Lung, Bronchiole - Foreign body in a male Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The plant material (bedding or feed) has incited a suppurative inflammatory response.
    Lung, Alveolus - Foreign body in a male Harlan Sprague-Dawley rat from a chronic study. A foreign body with associated suppurative inflammation is present in an alveolus.
    Lung, Alveolus - Foreign body in a female Wistar Han rat from a chronic study. A foreign body is present in an alveolus, with associated granulomatous inflammation.
    Lung, Bronchiole - Foreign body in a male Wistar Han rat from a chronic study. A hair fragment (arrow) is present in a bronchiole.
    Lung, Bronchiole - Foreign body in a male Wistar Han rat from a chronic study (higher magnification of Figure 5). The hair fragment (arrow) has incited an inflammatory reaction and an ulcer in the adjacent epithelium.
    Lung, Bronchiole - Foreign body in a female F344/N rat from a chronic study. Inflammation and epithelial hyperplasia associated with a hair shaft is present in a bronchiole.
    Lung, Alveolus - Foreign body in a female F344/N rat from a chronic study. Corn oil from a gavage accident is present in the alveoli, with acute inflammation and hemorrhage.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC